三苯基锡(Ⅳ)荒酸酯Ph_3SnS_2CN(C_4H_8O)的合成、生物活性及晶体结构  

Synthesis, Bioactivity and Crystal Structure of Ph_3SnS_ 2CN(C_ 4H_ 8O)

作　　者：尹汉东[1] 王传华[1] 马春林[1] 房海霞[1] 刘国富[2] 

机构地区：[1]聊城大学化学系,聊城252059 [2]聊城大学生物系

出　　处：《应用化学》2003年第9期841-844,共4页Chinese Journal of Applied Chemistry

基　　金：教育部骨干教师基金;山东省自然科学基金 (Z2 0 0 1B0 2 )资助项目

摘　　要：利用三苯基氯化锡和吗啉荒酸钠反应 ,合成了三苯基锡三苯基锡 (Ⅳ )吗啉荒酸酯。通过元素分析、红外光谱、紫外光谱和核磁共振氢谱对其结构进行了表征。用X 射线单晶衍射测定了这 2个化合物的晶体结构。化合物为单斜晶系 ,空间群P2 (1) /c ,a =1 2 2 36 (5 )nm ,b =1 16 70 (5 )nm ,c =1 5 791(6 )nm ,β =99 0 6 1(5 )° ,Z =4 ,V =2 2 2 6 9(15 )nm3 ,Dc=1 5 2 8g/cm3 ,μ =1 348mm-1,R =0 0 2 6 2 ,wR =0 0 6 15。在该化合物中 ,锡原子呈五配位畸变三角双锥构型。Triphenyltin(Ⅳ) dithiomorpholinocarbamate Ph 3SnS 2CN(C 4H 8O) has been synthesized by reacting triphenyltin chloride with sodium dithiomorpholinocarbamate and characterized by elemental analysis, UV, IR and 1H NMR. The crystal of the compound is monoclinic with space group P2(1)/c, a= 1.223 6(5) nm, b=1.167 0(5) nm, c=1.579 1(6) nm, β=99.061(5)°, Z=4, V=2.226 9(15) nm 3, D c=1.528 g/cm 3, μ=1.348 mm -1, R=0.026 2, wR=0.061 5. The structure shows a distorted trigonal bidendate and five-coordinated configuration to the central tin atom. The in vitro antitumor activity of the complex against the human tumor cell lines, MCF-7, a mammary tumor, is examined. The ID 50(μg/L) value is 850.

关 键 词：三苯基锡(Ⅳ)吗啉荒酸酯 合成 生物活性 晶体结构 

分 类 号：O641[理学—物理化学]