α-对氯苯基甘氨酸的合成  

Synthesis of α-(p-Chlorophenyl)glycine

作　　者：徐尚成[1] 许志专[1] 王晓军[1] 万琴[1] 俞幼芬[1] 蒋木庚[2] 

机构地区：[1]江苏省农药研究所,南京210036 [2]南京农业大学理学院,南京210095

出　　处：《农药》2003年第8期12-14,共3页Agrochemicals

摘　　要：以对氯苯甲醛为起始原料 ,采用Strecker合成法制备α -氨基对氯苯乙腈 ,进而水解成相应的α-对氯苯基甘氨酸。在明确了影响反应的主要因素及其化学成因的基础上 ,采用改进的三组分溶媒体系 ,使反应效果得到明显改善 ,总收率达到 6 0 %左右。The efficient synthesis of α-(p-chlorophenyl)glycine,an important intermediate of arylpyrrole pesticides,has been achieved by employing the Strecker Synthesis.p-Chlorobenzaldehyde was used as starting material andα-amino-p-chlorophenylacetonitrile as precursor of α-(p-chlorophenyl)glycine.Based on afurther understanding of the reaction chemistry,a new solvent system was used,and thus the reaction was significantly improved with a good total yield of about 60%.

关 键 词：α-对氯苯基甘氨酸 合成 原料 Strecker合成法 三组分溶媒体系 

分 类 号：TQ450.4[化学工程—农药化工]