^(99)Tc^m标记的N-(邻甲硫基苯基)乙二胺和硫醇混配配合物的制备及生物分布  

SYNTHESIS AND BIODISTRIBUTION OF ^(99)Tc^m MIXED LIGAND COMPLEXES CONTAINING A TRIDENTATE N-(O-METHYLTHIOPHENYL)ETHYLENEDIAMINE AND MONODENTATE THIOLS

作　　者：段新红[1] 吕恭序[2] 

机构地区：[1]北京林业大学基础科学与技术学院,北京100083 [2]北京师范大学化学系,北京100875

出　　处：《核化学与放射化学》2003年第2期110-114,共5页Journal of Nuclear and Radiochemistry

摘　　要：合成了新的三齿配体N (邻甲硫基苯基)乙二胺(MTPEA),并经IR、元素分析、MS(FAB+)表征确认。确定了混配配合物99Tcm(L3,L1a)(L3为MTPEA,L1a为乙硫醇)和99Tcm(L3,L1b)(L1b为异丙硫醇)的最佳标记条件。标记物在小鼠体内的生物分布结果表明:这两种配合物都可以通过正常的血脑屏障,并在脑中有一定的滞留。在注射后2,30min,99Tcm(L3,L1a)的脑摄取值分别为2.09%/g和1.10%/g;99Tcm(L3,L1b)的脑摄取值分别为1.76%/g和1.08%/g。A new ligand N(OMethylthiophenyl)ethylenediamine(MTPEA) is synthesized and characterized by IR, MS(FAB+) and elemental analysis. The preparation of two 99Tcmmixedligand complexes is studied by ligand exchange reaction. At the same time, the optimal conditions for labelling are obtained. The biodistribution study shows that both complexes could thread the bloodbrain barrier and in brain for a certain time.

关 键 词：^99Tc^m 标记 N-(邻甲硫基苯基)乙二胺 硫醇 混配配合物 制备 生物分布 脑血流 脑显像剂 

分 类 号：TQ463[化学工程—制药化工] R981[医药卫生—药品]