血清前S_2抗原、抗体与HBV复制及肝损伤关系的临床研究  

The Clinical Study for Pre-S2 Antigen and Antibody in Serum Related to HBV Replication and Liver In jury

作　　者：韦嘉[1] 刘光裕[1] 

机构地区：[1]昆明医学院附一院传染科

出　　处：《昆明医学院学报》1992年第2期13-16,共4页Journal of Kunming Medical College

摘　　要：我们应用单克隆抗体ELISA法,平行检测了175例乙型肝炎患者血清中的前S,抗原、抗体,结果表明,无论HBV复制活跃与否,前S,抗原检出率无差别(P>0.05),血清中前S_2抗原、抗体皆阳性的患者,主要是慢性肝炎,血清转氨酶活性升高者也显著多于其它组(P<0.005)。对36例还进行了6～9个月的随访。我们的资料提示,前S,抗原不能作为HBV复制活跃的血清学标志,对前S,抗原特异的免疫应答可能同肝损伤有关,但其机制有待进一步探讨,平行检测前S,抗原,抗体能为乙型肝炎的预后诊断提供有用的信息。By means of using monoclonal antibody ELISA method, we detected simultaneously pre-S2 antigen and antibody in the serum of 175 patients who were infected with hepatitis B virus (HBV). The result sowed that prevelence of Pre-s2 had no difference when HBV replication active was irrespective (P>0.05). The patients whose Pre-S2 antigen and antibody are positive in the serum are mainly with chronic hepatitis B (P<0.05), cases of ALT activity eveluate are more than others (P < 0.005). of the 36 cases were on call for 6-9 monthes. Our paper sugested that the Pre-S2 antigen not be used as marker of HBV replication active. The special Immune response to Pre-S2 amtigen may have corelations with liver injury, but the mechanism should be furtherly studied. To detect Pre-S2 antigen and antibody simulteneously can provide available information of prognosis for hepatitis B.

关 键 词：前S2抗原 抗体 肝损伤 HBV复制 

分 类 号：R512.620.3[医药卫生—内科学]