糖尿病骨骼肌微血管基底膜超微改变图像分析  

Moprphometry of Ultrastructural Alteration in Basal Lamina of Muscular Capillaries in Patients with Diabetes

作　　者：张鸿飞[1] 刘汉钧[1] 刘爱武[1] 蒋绿芝 明庆华 何云[3] 

机构地区：[1]昆明医学院电镜室 [2]昆医附二院内科 [3]云南大学实验中心图像分析室

出　　处：《昆明医学院学报》1992年第3期35-37,共3页Journal of Kunming Medical College

摘　　要：本文对年龄相近的糖尿病病人及正常人各10例的股四头肌穿刺材料进行了透射电镜观察及其微血管基底膜厚度和面积体视学的平均值检验及方差检验,结果发现糖尿病组肌肉微血管基底膜明显增厚,与正常组在统计学上有显著性差异。作者认为骨骼肌活检透射电镜观察可以作为临床辅助诊断和判定预后的简易手段。Capillary alterations are the pathologic basis of organic complications of diabetes mellitus,and the thickening of basal lamina is the most important.According to so many morphological descriptions but so few morphometry in the past,the authors selected 10 cases of diabetes mellitus and 10 cases of normal control,and a small piece of the quadriceps muscle of the thigh was obtained by a puncture biopsy and observed under the TEM.The thickness of basal lamina of the muscle capillaries was measured with morphometry.The re- sult was similar to most cases reported.The controversial point is whether the basal lamina thickening is a particular lesion of diabetes mellitus.Our control group was the same age as the diabetic group,and there was a very significant difference between the diabetic and the control when checking the thickness and the area of their basal lamina relatively with T-test and analysis of variance.We believe that the opinion that the thickening of basal lamina is a particular lesion of diabetes mellitus is reliable.So,a skeletal muscle biopsy and a TEM exam- ination can help to make a diagnosis of diabetes mellitus conveniently.

关 键 词：透射电镜 糖尿病 血管基底膜 

分 类 号：R587.104[医药卫生—内分泌]