人精浆抗精子抗体与顶体酶活性关系的探讨  

The Effect of Semen Antisperm Antibody on Human Sperm Acrosin Activity

作　　者：刘睿智[1] 路英丽[1] 许宗革[1] 左文静[1] 辛暨丽[1] 王忠山[1] 

机构地区：[1]吉林大学基础医学院细胞生物学教研室,吉林长春130021

出　　处：《中华男科学杂志》2003年第4期252-253,共2页National Journal of Andrology

基　　金：吉林省计划委员会资助 (1999)

摘　　要：目的 :研究精浆抗精子抗体 (AsAb)对精子顶体酶活力的影响。　方法 :用间接血凝法测定 34 32例不育男性和 6 5例生育男性精浆的AsAb ,并对其中的 2 882例不育男性精子用比色法进行了顶体酶活性的测定。　结果 :34 32例不育者精浆AsAb阳性率为 10 .2 0 %,2 882例进行了顶体酶活性测定的不育者精浆AsAb阳性率为 9.37%,对照组精子顶体酶活性明显高于各不育组 (P <0 .0 0 1)。不育组AsAb阳性组与AsAb阴性组比较顶体酶活性没有明显差异 (P >0 .0 5 ) ,顶体酶活性正常与异常组AsAb阳性率比较差异无显著性 (P >0 .0 5 )。　结论 :精浆AsAb对精子顶体酶活性没有影响。Objectives: To study the effect of antisperm antibody(AsAb) on human sperm acrosin activity. Motheds: AsAb and sperm acrosin activity were measured and analyzed in 3 432 infertile men and 65 fertile volunteers. Results: AsAb positive rate was 10.20% in 3 432 case of male infertility, and 9.37% in 2 882 infertile males who received tests of sperm acrosin activity. Acrosin activity of infertility cases were lower than those of fertile cases(P< 0.001). The comparison between AsAb positive group and AsAb negative group infertility cases showed no significant differences of acrosin activity (P> 0.05). Between normal acrosin activity group and abnormal acrosin activity group, there was no significant difference of AsAb positive rate (P> 0.05). Conclusions: Antisperm antibody could not affect acrosin activity.

关 键 词：男性不育 精浆 抗精子抗体 精子顶体酶活性 

分 类 号：R698.2[医药卫生—泌尿科学]