精子膜抗原的研究新进展  

Advances in Sperm Membrane Antigens

作　　者：戈一峰[1] 黄宇烽[1] 

机构地区：[1]南京军区南京总医院生殖遗传中心，江苏南京210002

出　　处：《中华男科学杂志》2003年第4期292-295,共4页National Journal of Andrology

摘　　要：精子表面的膜抗原是精子发生成熟过程中的重要标志分子 ,对其深入研究有助于揭示精子发生成熟及受精过程的生理机制和不育的病理改变。本文回顾了近年来随着分子生物学技术的广泛应用 ,传统的一些重要的精子膜抗原相继得到了克隆和测序 ,一些新的表达精子膜抗原的基因也陆续被发现 ,为从蛋白水平进一步深入研究其功能以及免疫避孕疫苗的筛选奠定了基础。A series of sperm membrane antigens, the important molecular markers associated with the program of spermatogenesis and maturation of sperm, which also are for attachment of the physiological mechanism of the sperm-egg interaction and fusion and the pathological changes in the infertility, were reviewed. Some traditional crucial sperm membrane proteins, such as FA-1, PH-20, fertilin, have been cloned and sequenced, and some novel gene which encode new proteins associated with the sperm membrane also have been screened out successionally. All of these provided a basement for lucubration of these proteins and the research of the contraception vaccine.

关 键 词：精子膜抗原 不育症 精子蛋白受精素 避孕 免疫性不育 

分 类 号：R392[医药卫生—免疫学]