川芎嗪对大鼠脑梗塞区细胞Ca^(2+)影响的实验研究  

Effect of Ligustrazine on Ca^(2+) in Cerebral Infarct Areas——An Experimental Study in Rats

作　　者：耿东进[1] 赵一瑜 胡大萌[2] 

机构地区：[1]上海第二医科大学仁济医院神经内科,上海200001 [2]上海第二医科大学瑞金医院神经科

出　　处：《老年学杂志》1992年第5期301-302,共2页

摘　　要：本实验用雄性大白鼠24只随机分成三组:A组(n=8)为对照组,在MCAO前30分钟静注蒸馏水;B组(n=8)在MCAO前30分钟静注川芎嗪lmg/kg;C组(n=8)在MCAD后40分钟静注川芎嗪lmg/kg。用钙离子选择性微电极观察脑梗塞区细胞外Ca^(2+)动态变化。结果显示B组脑梗塞区细胞外Ca^(2+)下降明显低于A组(P<0.05);C组给药前后自身对照脑梗塞区细胞外Ca^(2+)回升不显著(P>0.05)。提示缺血前30分钟用药川芎嗪能预防脑缺血区细胞外Ca^(2+)进入细胞。In our experiments, twenty-four rats were divided into three groups. Group A (n=8), the contrapositive group: water 30 minutes before MCAO; Group B (n=8), ligustrazine lmg/kg 30 minutes before MCAO; Group C (n=8): ligustrazine lmg/kg 40 min after MCAO. The changes of Ca^(2+) in the infarct areas were determined with Ca^(2+)-ISMs. The conentration of extracellular Ca^(2+) in the infarct areas of group B decreased less than group A (P<0.05); but the concentration of extracellular Ca^(2+) in infarct areas before using ligutrazine did not increase as compared with the group after using ligustrazine (P>0.05).

关 键 词：川芎嗪 脑栓塞 钙离子 

分 类 号：R282.710.5[医药卫生—中药学]