乙型病毒性肝炎患者血清可溶性白细胞介素2受体测定的意义  

The significance of serum soluble interleukin 2 receptors in the patients with hepatitis B

作　　者：林德馨[1] 高永琳[1] 黄伟明[1] 何艳[1] 叶庆林[1] 

机构地区：[1]福建医科大学生物化学与分子生物学系,福州350004

出　　处：《临床肝胆病杂志》2003年第4期222-223,共2页Journal of Clinical Hepatology

基　　金：福建省科委资助项目 (批准号 99-Z14 )

摘　　要：检测乙型病毒性肝炎患者血清可溶性白细胞介素 2受体 (sIL - 2R)的水平及其与血清丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、凝血酶原活动度 (PTA)、胆碱酯酶 (ChE)及乙肝病毒复制标志物之间的关系。采用酶联免疫法 (ELISA)检测 77例乙型病毒性肝炎患者和 2 0例正常人血清sIL - 2R含量。乙型病毒性肝炎患者血清sIL - 2R水平显著高于正常人 ,并且其升高与ALT、AST、PTA、ChE相关 ,与乙肝病毒的存在和复制与否无关。急性、慢性、重型乙型病毒性肝炎及乙肝后肝硬化患者血清sIL -To study the serum level of sIL-2R and the relationships between sIL-2R and liver injury of patients with acute and chronic hepatitis B. The level of sIL-2R was measured by a monoclonal and polyclonal antibody ELISA.The levels of sIL-2R of patients with acute and chronic hepatitis B were significantly higher than those in healthy subjects. The sIL-2R levels in the patients with hepatitis B correlated well with ALT, AST, PTA and ChE. The serum levels of sIL-2R in patients with acute and chronic hepatitis B are increased obviously and reflecting the immune function, degree of liver cells damage and inflammation of the patients.

关 键 词：乙型病毒性肝炎 血清可溶性白细胞介素2受体 测定 天冬氨酸氨基转移酶 胆碱酯酶 

分 类 号：R512.62[医药卫生—内科学]