地塞米松纳米粒子的制备及体内抑制血管再狭窄的研究  

Prepare and effect of dexamethasone nanoparticles on inhibiting restenosis

作　　者：武莉[1] 杨菁[1] 宋存先[1] 朱振峰[1] 曾勇[2] 朱文玲[2] 孙洪范[1] 唐丽娜[1] 王彭延[1] 

机构地区：[1]中国医学科学院生物医学工程研究所,天津300192 [2]北京协和医院心内科,北京100730

出　　处：《中国心血管杂志》2003年第4期249-251,共3页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金项目 (3 9870 196)

摘　　要：目的　制备地塞米松纳米粒子并应用于动物模型验证其效果。方法　采用 PL GA为载体 ,制备了地塞米松纳米粒子 ,对其进行了表征。结果　纳米粒子粒径在 2 5 0 nm左右 ,载药量高达 17%以上 ,包封率为 97% ,可维持长时间稳定的体外释放 ,应用于兔球囊损伤模型 ,明显抑制了血管内膜增生 ,取得了较好的效果。Objective To prepare dexamethasone nanoparticles and to use it in animal models. Methods In this study, biodegradable co-polymer polylactic-polyglycolic acid (PLGA) was used as carrier matrix to prepare nanoparticles which contains dexamethasone, the nanoparticles were characterized. Results Nanoparticles' size is about 250nm, the drug in nanoparticles is above 17% and about 97% dexamethasone contains in nanoparticles, It can release with same ratio long time,neointimal formation is decreas sed by using dexamethasone nanoparticles in rabbit iliac balloon injury model. Conclusion Nanoparticle is a good kind of drug delivery system.

关 键 词：纳米粒子 再狭窄 地塞米松 

分 类 号：R541.4[医药卫生—心血管疾病] R944[医药卫生—内科学]