人细小病毒B19感染与儿童血液疾病的关系  

Study of Relationship Between Human Parvovovirus B19 Infection and Children's Hematological Diseases

作　　者：曾佑群[1] 刘瑜[1] 张振琪[1] 

机构地区：[1]重庆医科大学儿童医院,重庆400014

出　　处：《实用医技杂志》2003年第6期569-570,共2页Journal of Practical Medical Techniques

摘　　要：目的:了解儿童血液病人(白血病、血小板减少性紫癜、贫血)细小病毒B19(Human parvovirus B19,HPVB19)感染的状况及其关系。方法:应用酶联免疫法(ELISA)测定血液中HPVB19-IgM,共检测白血病患儿158例,血小板减少性紫癜(ITP)281例,贫血患儿102例,共计541例。结果:158例白血病患儿血清HPVB19-IgM阳性51例,阳性率32.3％,281例ITP患儿阳性97例,阳性率34.5％,102例贫血患儿中阳性56例,阳性率为54.9％,总阳性率为40.6％。结论:HPVB19感染可能与儿童血液病发病有关,进行化疗时白血病患儿易继发HPVB19感染,并可致骨髓抑制和慢性贫血。Objective To reseach the condition of human parvovirus B19 (HPVB19) infection in children's hematological disease (leukemia, idiopathic thrombcytopenic purpura, anaemia) and the relationship between them. Methods Levels of HPVB19-IgM in plasma of 541 cases of children were determined with enzyme linked immunosobent assay (ELISA) method, including 158 leukemia, 218 ITP, and 102 anaemia cases. Results The positive cases of HPVB19-IgM in plasma of leucocythemia, ITP and anaemia cases were 51, 97 and 56 cases respectively, the positive rate were 32. 3 % , 34. 5 % and 54. 9 % respectively. The total positive rate was 40. 6 %. Conclusion The infection of HPVB19 may associate with the children's hematological disease. The infection of HPVB19 often occurs in children with leucocythemia treated by chemotherapy, and causes the bone marrow depression and chronic anaemia.

关 键 词：人细小病毒B19感染 儿童 血液疾病 酶联免疫法 测定 血液 HPVB19-IgM 

分 类 号：R725.5[医药卫生—儿科]