肾移植中HLA氨基酸残基配型模式的临床研究  

A clinical study of amino acid residues model in renal transplantation

作　　者：张卫民[1] 阎莉娜 于大海[1] 

机构地区：[1]天津市第三中心医院,300170 [2]天津市中心血站

出　　处：《河北医药》2003年第7期483-484,共2页Hebei Medical Journal

摘　　要：目的　研究氨基酸残基配型在肾脏移植中的意义。方法　按氨基酸残基配型模式 ,对 3 95例肾移植患者进行分析。结果　按各位点单一配型同氨基酸残基配型比较发现 ,A位点从 0MM的6.5 8%提高至 2MM的 2 9.11%,B点从 0MM的 2 .5 3 %提高至 2MM的 2 0 .0 %,DR位点从 0MM的 4.81%提高至 2MM的 15 .95 %,两种配型方法之间差异非常显著 (P <0 .0 1)。同样 ,综合HLA A、B、DR六个位点亦是如此。结论　按照氨基酸残基配型将提高肾移植供受者的配合率 ,增加移植肾的存活率 。Objective To study the clinical signifcance of amino acid residues model in renal transplantation.Methods To analyze the amino acid residues model in 395 cases of renal transplantation.Results The single location typing analysis found that the percentage of location A was increased from 6.58% to 29.11%;the percentage in location B was increased from 2.53% to 20.0%;while for another location DR,the percentage was increased from 4.81% to 15.95%.There was a significant difference between two typing methods (P<0.01).The same results were found in all the six locations.Conclusion The amino acid residues model typing method can increase matching ratio between donor and recipient in renal transplantation,and enhance the livability of the transplanted kidney and reduce the rejection probability.

关 键 词：肾移植 HLA配型 氨基酸残基配型 排斥反应 

分 类 号：R699.2[医药卫生—泌尿科学]