手性相转移催化剂的合成和不对称诱导效应  

Synthesis and Asmmetric Induction Effect of Chiral Phase Transfer Catalysts

作　　者：焦晓云[1] 华玉夏[1] 矫桂丽[1] 刘文陆[1] 邹志琛[1] 

机构地区：[1]山东师范大学化学化工与材料科学学院,山东济南250014

出　　处：《青岛科技大学学报（自然科学版）》2003年第4期321-323,共3页Journal of Qingdao University of Science and Technology:Natural Science Edition

摘　　要：以氯霉素为原料 ,经水解、苄基化、季铵化合成了光学纯 ( 1 S,2 R) - ( - ) - 1 -对硝基苯基 - 1 ,3-二羟基 - 2 -丙基苄基二甲基溴化铵。作为相转移催化剂 ,它对苯乙腈的 α-甲基化。S,2R) ( ) (1 para nitrophenyl 1,3 dihydroxyl 2 propyl)benzyldimethyla mmonium bromide was synthesized through hydrolysis,tert amination and quaterisation by using chloramphenicol as starting material.As a phase transfer catalyst, it shows a good catalysis and certain effect of asmmetric induction in α methylation of phenylacetonitrile and in addition of benzaldehyde with chloroform.

关 键 词：手性相转移催化剂 合成 不对称诱导效应 氯霉素 原料 水解 苄基化 季铵化 

分 类 号：TQ426.94[化学工程] O643.36[理学—物理化学]