白癜风患者血浆和皮肤组织液内皮素1的测定  

Detection of Endothelin-1in the Plasma and Skin Tissue Fluid of Patients with Vitiligo

作　　者：管晓春[1] 何颖红[1] 崔璐玲[1] 陈峻[2] 曾志良[1] 郑义[1] 

机构地区：[1]武汉市第一医院皮肤科,武汉430022 [2]武汉市第一医院同位素科

出　　处：《中国中西医结合皮肤性病学杂志》2003年第1期27-28,共2页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的了解白癜风患者血浆和皮肤组织液内皮素1(ET-1)水平,并讨论其临床意义。方法采用放射免疫方法对30例白癜风患者和12例健康体检者血浆中ET-1水平进行测定,以及对20例稳定期白癜风白斑部位和对侧部位非白斑的皮肤组织液中ET-1水平进行测定。结果患者白斑部位皮肤组织液ET-1值明显低于非白斑部位(P<0.01);白癜风患者血浆ET-1水平与正常人群差异无显著性(P>0.05)。结论在白癜风色素恢复过程中不仅受黑素细胞存在与否的影响,还与邻近角质形成细胞ET-1分泌功能异常有关。Objective To study the levels of endothelin-1as well as their significance in the plasma and skin tissue fluid of patients with vitiligo.Methods To measure the levels of ET-1in the plasma from30patients with vitiligo,12health of control group,and in the tissue fluid from skin lesion and uninvolved normal skin from20patients with vitiligo by using the method of radio-immunity.Re sults The levels of ET-1in tissue fluids from the skin lesion were significantly lower than that in uninvolved(P<0.01)from patients with vitiligo in stable stage.The plasma levels of ET-1in patients with vitiligo in progressive stage were no significantly differences compared with those of the health control group(P>0.05).Conclu sion The pigment rejuvenation pathogenesis of vitiligo is related not only to the presence or absence of melanocytes but also to the abnormal ET-1secreted from contiguous keratinocytes.It is suggested that the auto-transplan-tation of the mixed epidermal cells is superior to that of the pure melanocytes.

关 键 词：白癜风 血浆 皮肤组织液 内皮素1 测定 临床意义 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]