脑安胶囊不同制剂对大鼠血小板聚集的影响  

Effects of different preparations of Naoan capsules on platelet aggregation in rats

作　　者：张旭静[1] 范柳[1] 王春安[1] 王桂清[1] 

机构地区：[1]上海市脑血管病防治研究所,上海市200433

出　　处：《中国临床康复》2003年第19期2680-2681,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的观察两种不同工艺制剂的脑安胶囊(新型及传统型)对血小板聚集的影响,为研制活血化瘀类中药的新工艺提供了依据。方法大鼠60只,单纯随机分为6组,每组10只,分别为空白对照组(生理盐水),新型脑安胶囊低剂量组(40mg/kg)和高剂量组(80mg/kg)、传统型脑安胶囊低剂量组(40mg/kg)和高剂量组(80mg/kg),阿司匹林组(300mg/kg);实验药物经口灌胃,1次/d,连续给药3d后取血测定血小板的聚集率,并计算出聚集抑制率。结果新型脑安胶囊高剂量、传统型脑安胶囊高剂量和阿司匹林对血小板聚集抑制率分别为66.4%,57.4%和49.5%,经统计学分析,两种脑安胶囊高剂量对血小板聚集抑制率均超过阿司匹林(t=2.7-5.1,P<0.01,P<0.05),其中新型脑安胶囊高剂量与传统型脑安胶囊高剂量对血小板聚集抑制率相比较差异亦有显著性意义(P<0.01)。结论新型脑安胶囊对血小板的抑制作用明显高于传统型脑安胶囊。Aim To study the effects of two different technique preparations of Naoan capsules on platelet aggregation so as to provide new technique for Huoxuehuayu traditional Chinese medicine.Methods Sixty SD rats were randomly divided into 6 groups of 10 animals in each group. Rats of the 6 groups were fed orally with different drugs into the stomachs once a day for 3 days according to the following scheme: group A was given normal saline; group B was given 40 mg/kg (low dose) of modified Naoan capsules; group C was given 80 mg/kg(high dose) of modified Naoan capsules; group D was given 40 mg/kg (low dose) of traditional Naoan capsules; group E was given 80 mg/kg(high dose) of traditional Naoan capsules; group F was given 300 mg/kg of aspirin.Blood samples were then taken from the rats for assaying platelet aggregation.Results The inhibition rates of high dosage modified Naoan capsules, high dosage traditional Naoan capsules and aspirin were 66.4% , 57.4% and 49.5% respectively.According to the statistic analysis, two types of high dosage Naoan capsules showed a stronger inhibition in platelet aggregation than aspirin(t= 2.7- 5.1,P< 0.01,P< 0.05).There was also a significant difference between the high dose of modified and traditional Naoan capsules in inhibition of platelet aggregation(P< 0.01).Conclusion Modified Naoan capsules show a much stronger inhibition in platelet aggregation than traditional ones.

关 键 词：脑安胶囊 大鼠 血小板聚集 活血化瘀 低剂量 高剂量 

分 类 号：R286.1[医药卫生—中药学] R285.5[医药卫生—中医学]