人工肝支持系统治疗慢性重型肝炎时对电解质影响的临床观察  

Clinical observation on serum electrolyte in the treatment of chronic severe hepatitis with artificial liver support system

作　　者：庄鹏[1] 江元森[1] 李学俊[1] 谢俊强[1] 邓友[1] 王海霞[1] 姚集鲁[1] 

机构地区：[1]中山大学第三医院人工肝研究室,广州510630

出　　处：《中国血液净化》2003年第8期439-441,共3页Chinese Journal of Blood Purification

基　　金：99No .4 90 5G广东省重点科技攻关项目

摘　　要：目的　观察慢性重型肝炎患者CHDF(持续缓慢血液透析滤过 ) +PE(血浆置换 )治疗时对血清电解质的影响情况。方法　随机选取 5 5例慢性重型肝炎患者 ,其中并发低钾血症 2 1例 ,低钠血症 2 0例 ,低氯血症 2 7例 ,在内科综合治疗的基础上加用日产KM - 880 0血浆交换仪并联用JUN - 5 0 0血液透析滤过仪进行人工肝治疗 ,观察治疗前后的血清K+ 、Na+ 、Cl-、HCO3 -、Ca+ + 的变化情况。结果　人工肝治疗前后血清K+ 、Na+ 、Cl-水平有明显差异 (P <0 .0 5 ) ,HCO3 -、Ca+ + 水平无明显变化 (P >0 .0 5 )。结论　CHDF +PE治疗慢性重型肝炎可有效纠正电解质紊乱 ,保持内环境平衡。Objective To observe the influence on serum electrolyte in the treatment of chronic severe hepatitis with continuous hemodiafiltration(CHDF) plus plasma exchange(PE). Methods Fifty-five patients with chronic severe hepatitis were selected randomly, 21cases of them complicated with hypokalemia, 20 cases complicated with hyponatremia, 27 cases complicated with hypochloraemia. All patients were treated with PE and CHDF with an artificial liver support system of KM-880 and JUN-500 on the basis of general treatment before and after the treatment, the serum levels of electrolyte including K +、Na +、Cl -、HCO 3 -、Ca ++ were compared. Results The patients' serum levels of electrolyte K +、Na +、Cl - showed significant difference after the treatment (P<0.05), but the serum levels of electrolyte HCO 3 - 、Ca ++ 、have a different result(P>0.05). Conclusion CHDF plus PE can effectively rectify the disturbance of electrolyte and keep the balance of internal environment of the patients with chronic severe hepatitis.

关 键 词：慢性重型肝炎 人工肝支持系统 治疗 电解质 临床观察 

分 类 号：R512.6[医药卫生—内科学] R318.14[医药卫生—临床医学]