丙型肝炎患者血清TGF-β_1检测的临床意义  

Clinical significance of detection of serum TGF-β_1 in patients with hepatitis C

作　　者：刘雁雁[1] 朱天礼[2] 

机构地区：[1]江苏省人民医院传染病实验室,江苏南京210029 [2]江苏省南京鼓楼医院传染病实验室,210024

出　　处：《淮海医药》2003年第5期351-352,共2页Journal of Huaihai Medicine

摘　　要：目的　探讨转化生长因子 TGF-β1 在丙型肝炎患者中的发生和发展的作用。方法　应用酶联免疫吸附 ( EL ISA)方法对 4 0例丙型肝炎患者进行了血清 TGF- β1 含量测定 ,并与 35名正常健康人作对照。结果　丙型肝炎患者血清 TGF- β1 含量高于正常人组 ,且与肝功能损伤指标 AL T、TBi L 呈正相关。结论　测定丙型肝炎患者血清中 TGF-β1 含量对判断患者的病情变化具有十分重要的临床价值。Objective To explore the effect of transforming growth factor β 1(TGF β 1) on the development of hepatitis C.Methods Level of TGF β 1 in serum were detected with ELISA method in 40 patients with hepatitis C and 35 normal controls.Results The level of TGF β 1 in patients with hepatitis C was higher than that in the normal controls( P <0.01).Significant positive correlation was found between serum levels of TGF β 1 and serum ALT and total bilirubin.Conclusion Detection of serum TGF β 1 might be one of the important parameters for clinical evaluation in patients with hepatitis C.

关 键 词：丙型肝炎 血清 TGF-Β1 临床意义 含量测定 酶联免疫吸附 

分 类 号：R512.63[医药卫生—内科学] R446.11[医药卫生—临床医学]