青年长期吸烟者血管内皮依赖性舒张功能的改变  

Change of endothelium-dependent dilatation function of brachial artery in young long-term smokers,

作　　者：邢爱红[1] 姜志明[2] 刘军生[2] 李涛[2] 

机构地区：[1]山东省卫生学校,山东济南市250002 [2]山东省千佛山医院,山东济南市250014

出　　处：《心血管康复医学杂志》2003年第4期292-294,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨青年长期吸烟血管内皮依赖性舒张功能的改变。方法:测定20例长期吸烟青年及15例正常对照者血流介导的和硝酸甘油介导的肱动脉内径改变。结果:两组肱动脉内径基础值(3.75±0 61mm:3.81±0.55mm)及硝酸甘油介导的肱动脉舒张[(22.13±7.65)％:(23.45±8.21)％]无显著差异(P>0.05),而血流介导的血管扩张存在显著差异.为[(3.61±2.90)％:(8.32±4.75)％]、P<0.01。单因素相关分析表明,肱动脉内皮依赖件舒张与吸烟量呈显著负相关(r=0.523.P<0.001).结论:青年长期吸烟者血管内皮依赖性舒张功能明显受损,受损程度与吸烟量有关。Objective: To study the change of endothelium-dcpendent dilatation function of brachia! artery in young long term smokers. Methods: The internal diameters of brachial arteries of flow-mediate (FMD) and glyceryl trinitrate-induced (GTN-induced) were measured in 20 cases young long-term smokers and 15 controls (no smoking). Results: The basic internal diameter of brachial artery and GTN-induced dilatation of brachial artery had no difference (P>0. 05) while FMD dilatation had significantly difference [ (3. 61±2.90)% : (8. 32 + 4. 75)%] ( P<0. 01). Endothelium-dependent dilatation of brachial artery was negatively associated with quantity of cigarette. Conclusion: The function of endotheiium-dependent dilatation of brachial artery in young long-term smokers is significantly damaged and their damage degree is significantly correlation with quantity of cigarette.

关 键 词：青年 长期吸烟 血管内皮依赖性舒张功能 硝酸甘油介导 血流介导 

分 类 号：R163[医药卫生—公共卫生与预防医学] R331.32