前列腺素E1在高氧肺损伤中的保护作用  

LUNG PROTECTIVE EFFECT OF PROSTAGLANDIN E1 IN ACUTE LUNG INJURY INDUCED BY HYPEROXIA

作　　者：袁跃西[1] 尹邦良[2] 

机构地区：[1]长沙市中心医院胸外科,410004 [2]中南大学湘雅二医院心胸外科,长沙410011

出　　处：《中国现代医学杂志》2003年第12期43-45,共3页China Journal of Modern Medicine

摘　　要：目的 :研究前列腺素E1对高氧诱导的急性肺损伤是否有保护作用。方法 :4 0只雄性SD大鼠被随机分成四组。分别予腹腔注射生理盐水或前列腺素E1(PGE1)后暴露于 2 1%O2 或 95 %O2 72h ,分别测定支气管肺泡灌洗液 (BALF)中的总蛋白 (TP)、乳酸脱氢酶 (LDH)、粒细胞数及血清总蛋白 ,并作肺组织形态学观察。结果 :PGE1腹腔注射组暴露于高氧后BALF中的TP ,LDH及粒细胞数量较使用生理盐水的高氧暴露组显著下降 ,而血清总蛋白无显著性差异。肺组织石蜡包埋切片HE染色 ,光镜下观察高氧暴露组肺组织水肿。结论 :高氧可诱导急性肺损伤 ;PGE1对高氧诱导的肺损伤有保护作用。Objective:To determine whether prostaglandin E1 (PGE1) attenuates pulmonary oxygen toxicity.Methods:Fifty male Sprague-Danley rats were divided randomly into four groups. The animals were injected intraperitoneally with saline or PGE1 and immediately exposed to either 21%O 2 or 95%O 2 for 72 hours. Lactate dehydrogenase (LDH) activity, total protein content, and numbers of granulocytes were measured in the bronchoalveolar lavage fluid and serum.Results:LDH activity, protein content,and numbers of granulocytes was significantly decreased ( P <0.01) in these animals treated with PGE1 prior to and in exposure to hyperoxia compared with those animals exposed to hyperoxia and not treated with PGE1.Conclusions:Hyperoxia can induce acute lung injury and PGE1 can attenuate pulmonary oxygen toxicity.

关 键 词：肺损伤 前列腺素EL 高浓度氧 

分 类 号：R655.3[医药卫生—外科学]