抗环瓜氨酸肽抗体检测与类风湿性关节炎早期诊断  

THE DETECTION OF ANTICYCLIC CITRULLINATED PEPTIDE ANTIBODY AND THE EARLY DIAGNOSIS OF RHEUMATOID ARTHRITIS

作　　者：梁日初[1] 李跃进[2] 

机构地区：[1]中南大学湘雅医院检验科,长沙410008 [2]中南大学湘雅医学院八九级检验系

出　　处：《中国现代医学杂志》2003年第13期85-86,89,共3页China Journal of Modern Medicine

摘　　要：目的 :探讨抗环瓜氨酸肽抗体 (抗CCP抗体 )对类风湿性关节炎 (RA)早期诊断的意义。方法 :采用酶联免疫吸附法 (ELISA) ,了解抗CCP抗体在诊断RA中的敏感性和特异性 ;以及抗CCP抗体在类风湿性关节炎、系统性红斑狼疮、强直性脊柱炎中阳性率的关系。结果 :5 6例RA患者 (RF >30 .0IU/ML) ,抗CCP抗体的阳性率为 5 0 .0 % ;6 8例RA患者 (RF2 0 .0～ 30 .0IU/ML) ,抗CCP抗体阳性率为 4 4 .1%。抗CCP抗体对RA的敏感性和特异性分别为 5 0 .0 %和 95 .8%。 30例系统性红斑狼疮 (SLE)且ANA阳性患者 ,抗CCP抗体的阳性率为 10 .0 % ,2 5例强直性脊柱炎 (AS)且HLA -B2 7阳性患者 ,抗CCP抗体的阳性率为 4 .0 %。结论 :抗CCP抗体对RA具有很好的敏感性和特异性 ,且在RF2 0 .0～ 30 .0IU/ML患者中抗CCP抗体的阳性率为4 4 .1% ,结合临床症状能早期诊断RA ,故抗CCP抗体可作为RA血清学早期诊断指标。Objective:To explore the early diagnostic valve of anti-cyclic citmllinated peptide (CCP) antibody (Anti-CCP) detected by ELISA in patients with rheumatoid arthritis.Methods:The anti-ccp was dectected by ELISA to detect the specificity and sensitivity of Anti-CCP, and analyze the correlation of Anti-CCP positive rate among RA, SLE,AS.Results:28(50.0%) patients (RF>30.0IU/ML), 30(44.1%) patients (RF20.0～30.0IU/ML) were found to be Anti-CCP positive. The sensitivity of Anti-CCP was 50.0% with hige specificity (95.8%)in RA. The positive rate of Anti-CCP in the patients with SLE(ANA positive),AS(HLA-B27 positive)was 10.0%,4.0%.Conclusions:Anti-CCP presents a reasonable sensitivity (50.0%) with high specificity (95.8%) to RA and the positive rate of Anti-CCP in patients with RF20.0～30.0IU/ML is 44.1%, it is valuable to RA early diagnosis. So it could be regarded as a early diagnostic marker in RA.

关 键 词：类风湿性关节炎 抗CCP抗体 酶联免疫吸附试验 抗核抗体(ANA) 人类白细胞抗原 

分 类 号：R446.62[医药卫生—诊断学]