一种评价离子选择性电极综合性能的新方法及其在盐酸强力霉素PVC膜选择性电极研制中的应用  

An New Evaluation on Comprehensive Quality of Ion-selective Electrode and its Application in Development of Doxycycline-Selective PVC Membrane Electrode

作　　者：孙贤祥[1] 

机构地区：[1]江苏石油化工学院化工系,江苏常州213016

出　　处：《分析测试学报》2003年第4期1-4,共4页Journal of Instrumental Analysis

基　　金：江苏省教育厅科技基金资助课题 (01KJB150003)

摘　　要：以电极的响应斜率、响应线性、检出限和响应时间等参数 ,首次提出了一个评价离子选择性PVC膜电极综合性能的新方法———综合性能指数 (ICQ) ,应用ICQ 于以盐酸强力霉素 -四苯硼酸根为电活性物 ,以邻苯二甲酸二丁酯为增塑剂的盐酸强力霉素离子选择性电极的PVC膜成分优选 ;该电极在5.0×10-6～3.2×10-2mol/L范围内呈线性响应 ,斜率为54.5mV/pc,检出限为2.4×10 -6mol/L ;采用直接电位法测定药物片剂中的盐酸强力霉素的含量 ,方法的回收率为99.6%～100.1% ;研究发现 ,当溶液 pH>4时以盐酸强力霉素A comprehensive quality index(I CQ ),consisting of the response slope,linear concetration range,limˉit of detection and response time for an ion_selective electrode(ISE)or sensor,was proposed for evaluating the quality of the ISE or sensor.Based on the optimization of the composition of PVC sensing membrane,the pair compounds,doxycycline-tetraphenylborate(DC-TPB)and dibutylphthatate(DBP),were used to construct the doxycycline _ selective PVC membrane electrode by an orthogonal experimental design with the comprehensive quality index.The electrode has the linear concentration range of5.0×10 -6 ～3.2×10 -2 mol/L with a slope of54.5mV/decarde and a detection limit of2.4×10 -6 mol/L,and successfully applied in the pharmaceutical formulation of doxycycline hydrochloride.The recoveries obtained were99.6%～100.1%.Moreover,super_ Nernstian response was also observed with the DC-PTelectrode at pH>4,of which DC-phosphotungstate and DBP were used as the electroactive substance and plasticizer,respectively.

关 键 词：离子选择性电极 综合性能 评价方法 盐酸强力霉素 PVC膜电极 电位法 研制 四环族抗生素药物 

分 类 号：R978.14[医药卫生—药品] R917[医药卫生—药学]