硝基呋喃类药物呋喃唑酮的新极谱法测定  

Determination of Nitrofurans Drug Furazolidone in Tablets by Neopolarography

作　　者：王福民[1] 

机构地区：[1]渭南师范学院化学系,陕西渭南714000

出　　处：《分析测试学报》2003年第4期48-51,共4页Journal of Instrumental Analysis

基　　金：陕西省自然科学基金资助项目(2001H19) ;陕西省教育厅专项科研基金资助项目(01JK070)

摘　　要：在B -R(pH6.8)缓冲溶液中 ,呋喃唑酮(FZ)产生两个还原波 ;第一波 (电位 -0.30V)由NO2 基团经6电子还原为—NH2 产生 ,受吸附控制 ;第二波 (电位 -1.20V)由—CH‖N—N基团经4电子还原为—CH3和N—NH2 产生 ,受扩散控制 ;第一波可用于呋喃唑酮的测定 ,该波的2.5次导数峰峰电流ep″与呋喃唑酮浓度在2.0×10 -7～2.0×10 -5mol/L范围内呈线性关系(r=0.9984,n=7) ;11次平行测量4.0×10 -6mol/LFZ的峰电流 ,所得RSD为1.5 % ;In Britton-Robinson(pH6.8)buffer solution,furazolidone yields two reduction waves.The first wave at-0.30V(vs SCE)which forms via the six_electron reduction of NO 2 group to NH 2 is controlled by absorption,while the second at-1.20Vwhich forms via the four_electron reduction of-CH‖N-N group to-CH 3 and N-NH 2 is controlled by diffusion.The first wave,well_defined,can be applied to the determination of furaˉzolidone by2.5th_order derivative polarography,and its peak current is linear with furazolidone concentration in the range2.0×10 -7 ～2.0×10 -5 mol/L(r=0.9984,n=7).The relative standard deviation of2.5th_order derivative peak current is1.5%by performing11parallel measurements of4.0×10 -6 mol/L furazolidone.The proposed method can be applied to the direct determination of furazolidone in tablets.

关 键 词：硝基呋喃类药物 呋喃唑酮 极谱法 测定 药物分析 抗菌谱性 生理活性 

分 类 号：R978.25[医药卫生—药品] R917[医药卫生—药学]