用混合粘合剂修饰的碳糊电极测定诺氟沙星  

Voltammetric Determination of Norfloxacin Using Mixed Binder-modified Carbon Paste Electrode

作　　者：朱明芳[1] 宋粉云[1] 毋福海[2] 曾勇胜 曾常青[1] 黄庆华[1] 廖月镜[1] 

机构地区：[1]广东药学院药学系,广东广州510224 [2]广东药学院预防医学系,广东广州510224 [3]广东省阳西县卫生防疫站检验科,广东阳西529500

出　　处：《分析测试学报》2003年第4期98-100,共3页Journal of Instrumental Analysis

摘　　要：在pH10.50的磷酸盐缓冲溶液中 ,当含有0.8mmol/L的NH4Cl,8mg/L的SLS(十二烷基磺酸钠)时 ,诺氟沙星在由69.1% (w)的石墨粉、24.5 % (w)的液体石蜡和6.4 % (w)的甘油组成的混合粘合剂碳糊电极上产生一灵敏的阴极溶出还原峰 ,峰电位为 -1.61V ;峰电流与诺氟沙星浓度在8.0×10 -9～4.0×10 -7mol/L范围内呈良好的线性关系 ,相关系数为r=0.9949 ,检出限为3.0×10-9 mol/L ;该法用于测定诺氟沙星胶囊含量 。A mixed binder_modified carbon paste electrode containing69.1%(w)graphite powder,24.5%(w)liquid paraffin and6.4%(w)glycerol was prepared for the determination of norfloxacin.In an ortho_phosphate solution at pH10.50containing0.8mmol/L NH 4 Cl and8mg/L sodium laurylsulfonate,norfloxaccin yields a sensitive cathodic stripping voltammetric peak at-1.61V.The peak current was linear with the concentration of norfloxacin in the range of8.0×10 -9 ～4.0×10 -7 mol/L with a correlation coefficient of0.9949,the detection limit was3.0×10 -9 mol/L.This method is satisfying for the determination of norfloxacin capsules.

关 键 词：混合粘合剂 修饰 碳糊电极 测定 诺氟沙星 伏安法 喹诺酮类抗菌药物 

分 类 号：R978.19[医药卫生—药品] R917[医药卫生—药学]