透明质酸防治结核性胸腔积液胸膜肥厚的疗效分析  

The therapeutic effects of hyaluronic acid on preventing and treating pleural thickening in patients with tuberculous pleural effusion

作　　者：周爱莲[1] 郭兰萍[1] 唐良春[1] 吴平[1] 

机构地区：[1]广东医学院呼吸疾病研究所,广东医学院附属医院中心实验室,524001

出　　处：《新医学》2003年第8期480-481,共2页Journal of New Medicine

摘　　要：目的:观察胸腔内注射透明质酸防治结核性胸腔积液胸膜肥厚的疗效。方法:初治的有中等量结核性胸腔积液(B超示积液包裹及胸膜肥厚超过0.2cm)患者57例,随机分为治疗组32例和对照组25例,两组均按同样的抗结核方案治疗,治疗组抽胸腔积液后注入透明质酸2.5mL,对照组抽胸腔积液后注入生理氯化钠2.5mL,比较两组的疗效。结果:治疗组胸腔穿刺次数较对照组减少(P<0.05)、胸腔积液完全吸收时间较对照组显著变短(P<0.05)、肺功能指标明显优于对照组(P<0.05);治疗组注药后胸膜厚度犤(0.57±0.11)cm犦较注药前犤(0.92±0.15)cm犦减轻(P<0.05),与对照组比较其差异也具统计学意义(P<0.05)。治疗组注药后胸腔积液中的蛋白含量、白细胞数、纤维蛋白溶酶原激活物抑制物-1含量较注药前明显下降(均为P<0.05)。治疗组未见不良反应。结论:胸腔内注射透明质酸有防治结核性胸腔积液胸膜肥厚的作用。Objective:To evaluate the effects of hyaluronic acid on preventing and treating pleural thickening in patients with tuberculous pleural effusion. Methods:57 patients with moderate amount of tuberculous pleural effusion,fluid bound and pleura thickened more than 0.2 cm,were randomly divided into two groups. All patients were given standard treatments with anti tuberculous drugs. Hyaluronic acid was injected into intra thoracic cavity in the treatment group (32 patients),while normal saline was injected into intra thoracic cavity in the control group (25 patients). Therapeutic effects were compared between the two groups. Results:patients who treated with hyaluronic acid had significantly thinner pleura,lower proteins,lower white blood cell count and PAI 1 level in thoracic fluid,and higher FEV1%and FVC%values compared with the control group (P<0.05). Conclusion:Intra thoracic cavity injection of hyaluronic acid can prevent and treat pleural thickening in patients with tuberculous pleural effusion. [

关 键 词：透明质酸 结核性胸腔积液 胸膜肥厚 预防 治疗 疗效 

分 类 号：R521[医药卫生—内科学]