先心患儿体外循环过程中血清过氧化脂质含量的动态观察  

Observation of Serum Lipid Peroxide in Children with Congenital Heart Diseases undergoing Open Heart Surgery

作　　者：曾锐[1] 朱达清[1] 

机构地区：[1]武汉市儿童医院麻醉科

出　　处：《临床麻醉学杂志》1992年第3期127-129,共3页Journal of Clinical Anesthesiology

摘　　要：检测了20例先心患儿体外循环治疗过程中血清过氧化脂质(LPO)含量,发现术中 LPO 含量相对降低,术后开始升高。不伴肺动脉高压的 ASD 和 VSD 术后2周内 LPO 含量开始下降,而伴肺动脉高压者和 TOF 则持续升高。提示氧自由基与体外循环再灌流损伤有关,追踪检测 LPO 含量变化可能有助于判断预后。Serum lipid peroxide(LPO) was measured before,during and after cardiopulmonary bypass(CPB) respectively in 20 chil-dren with congenital cardiac diseases.It was found that LPO decreased during CPB and increased after CPB.LPO began to decrease within two weeks postoperatively in patients with ASD or VSD without pulmonary hypertension.But LPO remained increasing in patients with TOF and VSD with pulmonary hypertension.The results indicate that oxygen free radicals correlatedwith myocardial injury resulting from reperfusion during CPB.

关 键 词：儿童 先天性心脏病 手术 LPO 

分 类 号：R726.542[医药卫生—儿科]