草问荆总生物碱对小鼠脑单胺氧化酶-B活性的影响  

Effect of total alkaloids in Equisetum pratense on activity of MAO-B in mice brain

作　　者：季宇彬[1] 高世勇[1] 

机构地区：[1]哈尔滨商业大学药物研究所博士后科研工作站,黑龙江哈尔滨150076

出　　处：《中草药》2003年第8期728-729,共2页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省科委自然科学基金资助项目 ( D0 1- 0 5)

摘　　要：目的　研究草问荆总生物碱 (TAEP)对小鼠脑单胺氧化酶 -B(MAO-B)活性的影响 ,揭示 TAEP对中枢神经系统抑制作用的机制。方法　采用紫外分光光度法测定 MAO-B的活性。结果　TAEP对小鼠脑 MAO-B具有明显的激活作用 ,并具有对抗烟肼酰胺抑制小鼠脑 MAO-B活性的作用。结论　TAEP是 MAO-B的激动药 ,有单胺代谢作用 ,这可能是Object To study the effects of total alkaloids in Equisetum pratense Ehrh. (TAEP) on the activity of monoamine oxidase B (MAO B) in mice brain, to reveal the mechanism of its inhibitory action on the central nervous system (CNS). Methods The activity of MAO B was determined by UV spectrophotometry. Results TAEP can markedly activate MAO B in cerebrum and antagonise the inhibition of MAO B activity by nialamide. Conclusion TAEP is a MAO B agonist with an action for the evacuation of monoamine, this may be considered as one of the mechanisms of TAEP sedative and tranquilizing action on CNS.

关 键 词：草问荆总生物碱 单胺氧化酶—B 中枢抑制 

分 类 号：R286.1[医药卫生—中药学]