按指数曲线程序给药维持静脉麻醉稳定血药浓度—硫喷妥钠的研究  

Programmed Infusion to Maintain a Desired Plasma Concentration of Thiopentone

作　　者：王若松[1] 何丰[1] 施冲[1] 王卫权 张仁惠[1] 李复金[1] 

机构地区：[1]广州军区广州总医院

出　　处：《临床麻醉学杂志》1992年第5期270-272,共3页Journal of Clinical Anesthesiology

摘　　要：本研究基于血浆药物流出率的概念。应用指数曲线程序输注给药以维持预期硫喷妥钠血药浓度。药物输注由IBM-PC微机控制YBDS-11型输液泵自动进行。血浆硫喷妥钠由高效液相色谱仪检测。求得血浆药物流出率后重新拟合曲线得出如下公式Ep(t)=39.96e^(-.158t) +8.63e^(-.0145t)+7.66。应用此公式,第二组7例病人88次血药浓度检测结果为10.09±9.0μg/ml。最大血药浓度变化在±20％之内。The process of this study is based on the concept of plasma drug efflux. A polyexponential programmed infusion was used to meintain a desired plasma thiopental concentration. The study was implemented by an IBM--PC computer--assisted YBDS --11 infusion pump. Plasma thiopental concentrations were measrued by HPLC technique. By means of error correcting itera- tive process, a new equation was produced as following: Ep (t) = 39. 96exp^(-158t) + 8. 63e^(-. 0145t)+7. 66. The average of 88 plasma concentrations of seven patients was 10. 09±0. 90μg/ml, in which the maximum variation was within the range of ± 20% as expected (10μg/ml).

关 键 词：硫喷妥钠 静脉麻醉 血液 

分 类 号：R614.24[医药卫生—麻醉学]