大黄蔗虫丸抗肝纤维化作用的临床研究  

Clinical Study on Daihuang Zhechong Pill in the Treatment of Hepatic Fibrosis

作　　者：潘志恒[1] 程木华[1] 李林[1] 凌莉[2] 武敬[3] 陈艺[3] 

机构地区：[1]中山大学附属第三医院中医科,广州510630 [2]中山大学公共卫生学院,广州510020 [3]中山大学附属第三医院,研究生广州510630

出　　处：《中国中西医结合消化杂志》2003年第4期212-214,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：广东省中医药管理局科研基金项目 (No.995 6 0 )

摘　　要：目的 :观察大黄蔗虫丸对慢性肝病患者肝功能、血清肝纤维化标志物及 B超等指标的影响 ,探讨其可能存在的抗肝纤维化作用。方法 :用大黄蔗虫丸配合中药辨证治疗慢性肝病患者 36例 (治疗组 ) ,与单纯应用中药辨证治疗 32例 (对照组 )进行比较 ,观察治疗前后患者血清透明质酸 (HA)、 型前胶原 (PC )、 型胶原 ( - C)和层粘蛋白 (L N)的变化 ,观察期均在 6个月以上 ,并同时检测治疗前后的肝功能 [丙氨酸转氨酶 (AL T)、总胆红素(TBil)、白蛋白 (Alb)、球蛋白 (Glb) ]和 B超 (门静脉主干、脾静脉内径和脾厚 )等情况。结果 :治疗组患者血清肝纤维化标志物均明显下降 ,尤以 HA和 PC 下降明显 ,与治疗前比较差异有显著性意义 (P<0 .0 1) ,且治疗 6个月后肝纤维化标志物仍持续下降并接近正常组水平 (P>0 .0 5 ) ,治疗组各项指标的差值与对照组比较差异均有显著性意义 (P<0 .0 5 )。治疗后患者的肝功能指标 (AL T、TBil、Glb)均有不同程度的好转 (P<0 .0 5 ) ,多数患者的 B超指标有改善。结论 :大黄蔗虫丸可能具有减轻和抑制肝纤维化进程的作用。Objective: To observe the effect of Daihuang Zhechong pill (DZP) on the indexes of liver function, fibrosis and ultrasonic B examination in patients with chronic hepatitis, and explore its possible anti-fibrosis effect. Methods: Thirty-six patients with chronic hepatitis were treated with DZP as well as Chinese herbs decoction according to TCM criteria (treatment group). Thirty-two patients with chronic hepatitis were treated only with Chinese herbs decoction as the control group. Results: Liver fibrosis indexes in the treatment group declined significantly after 3 consecutive months, esp. HA and hPCⅢ, which were significantly lower than those before treatment (P<0.01). Moreover this tendency maintained after 6 consecutive months (P>0.05). Meanwhile the indexes of liver function (ALT, TBil and Glb)and ultrasonic B examination also showed obvious improvement(P<0.05). Conclusion: DZP could improve the liver function and slow down or reverse liver fibrosis process with stable long-term effect.

关 键 词：大黄蔗虫丸 肝纤维化 血清 透明质酸 Ⅱ型前胶原 Ⅳ型胶原 中医药治疗 

分 类 号：R259.752[医药卫生—中西医结合]