康脉注射液对股动脉硬化闭塞症家兔血管内皮细胞活性因子的影响  

Effect of Endothelial Activity Factors in Kangmai(康脉) Injection Treating Femoral Atherosclerosis Obliterans in Rabbits

作　　者：李令根[1] 徐恒[2] 许宇飞[3] 张毅奎[1] 聂浩劫[3] 李日恒[2] 吴明远[1] 

机构地区：[1]黑龙江中医药大学附属第一医院血管外科,哈尔滨150040 [2]黑龙江中医药大学 [3]黑龙江中医药大学附属第一医院放射线科

出　　处：《中国中西医结合外科杂志》2003年第4期262-263,共2页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的 :观察康脉注射液对股动脉硬化闭塞症家兔的血管内皮细胞活性因子的影响。 方法 :建立股动脉硬化闭塞症家兔模型 ,并观察康脉注射液对其血浆内皮素、一氧化氮等内皮细胞活性因子的影响。 结果 :股动脉硬化闭塞症家兔血浆中 ,血管紧张素 -Ⅱ (AT -Ⅱ )、内皮素 (ET - 1)、血栓素B2 (TXB2 )升高 ,一氧化氮 (NO)、6 -酮 -前列腺素1α(6 -K -PGF1α)、降钙素基因相关肽 (CGRP)降低。康脉注射液能够明显降低AT -Ⅱ、ET - 1、TXB2 ,提高NO、6 -K -PGF1α、CGRP ,且优于对照组。结论 :康脉注射液具有减轻内皮细胞的损伤 ,促进ET/NO、TXB2 / 6 -K -PGF1α趋向平衡。Objective To observe the effect of endothelial activity factors in Kangmai injection treating femoral atherosclerosis obliterans in rabbits Methods Rabbit model of femoral atherosclerosis obliterans were made and the levels of endothelins,nitric oxide and other endothelial activity factors were observed.Results Rabbits with femoral atherosclerosis obliterans had high levels of plasma endothelin(ET),thromboxan B 2(TXB 2)and angiothensin-Ⅱ(AT-Ⅱ),low leves of plasma nitric oxide gene(NO) calctionin gene related peptide(CGRP)and 6-ketoprostaglandin F 1α(6-K-PGF 1α),Kangmai injection obviously reduced ET,TXB 2,AT-Ⅱ and increased NO,CGRP,6-K-PGF 1α more markedly than in the control group. Conclusion Kangmai injection has the effects of qmeliorating injury of endothelial cells and promoting normalization of ET/NO,TXB 2 and 6-K-PGF 1α.

关 键 词：康脉注射液 股动脉硬化闭塞症 血管内皮细胞 活性因子 影响 

分 类 号：R543.5[医药卫生—心血管疾病]