冠心病患者血浆TXB_2和6酮PGF_1α浓度与冠脉病变的关系  

Plasma thromboxane B2 and 6 keto-prostaglandin F1α levels in patients with angiographically defined coronary obstructive lesions

作　　者：丁怀翌[1] 蔡伟菁 龚兰生[1] 沈卫峰[1] 张继盛 林淑英[1] 过鑫昌[1] 侯国英 吴春芳[1] 陈风云 华佳[1] 

机构地区：[1]上海第二医科大学瑞金医院心血管研究室,200025

出　　处：《临床心血管病杂志》1992年第1期11-13,共3页Journal of Clinical Cardiology

摘　　要：本研究为80例由于各种原因接受冠脉造影者测定血浆中TXB_2和6酮PGF_(1α),造影结果示无狭窄者37例,狭窄者43例;狭窄组TXB_2值较无狭窄组有增加趋势,而6酮PGF_(1α)值,两组无明显差别;狭窄组各分组比较,中度及重度狭窄分组TXB_2值较轻度狭窄分组显著增高(P<0.01,<0.05),6酮FGF_(1α)测值则随狭窄程度的加重逐渐减低。两者的比值更能反映TXB_2和6酮PGF_(1α)的比例失调在冠脉粥样硬化形成中的作用。Flasma TXB2 and 6 keto- FGF1α, levels of 80 subjects undergoing angicgra-phy Were measured in order to analyse their relationship. Among them, 37 showed normal coronary arteries, 43 showed coronary obstructive lesions of various degrees. The average TXB2 level of the obstructive group was higher than that of the normal group (P<0.01), while the average 6 keto-FGF1αlevels had no difference between the two groups. As devided into subgroups according to the severity of obstructive lesions, the TXB2 levels of the middle and severe group were significantly higher than that of the mild group (F< 0.01, <0.05), the 6 keto-FGF1α levels were lowering with the degree or severity. The ratio of the two 1evels were more likely shown the role of the disturbance of TXB2 and 6 keto-FGF1α relationship in the development of coronary artery atherosclerosis.

关 键 词：冠心病 前列环素 血栓素 

分 类 号：R541.402[医药卫生—心血管疾病]