纳曲酮用于海洛因依赖治疗  

NALTREXONE THERAPY FOR HEROIN ADDICTS

作　　者：刘运琴 戢汉兵 

机构地区：[1]武汉市武东医院戒毒科,武汉430084

出　　处：《中国药物依赖性杂志》2003年第3期198-200,共3页Chinese Journal of Drug Dependence

摘　　要：目的 :了解纳曲酮抗复吸治疗效果。方法 :采用回顾性临床资料分析方法 ,分析 5 0例海洛因依赖者躯体脱毒后使用纳曲酮抗复吸治疗的临床资料。结果 :应用纳曲酮抗复吸治疗 6个月 ,患者对海洛因渴求程度分值从1 96±s 0 88降至 0 2 5±s 0 4 4 (P <0 0 1) ,复吸率从 2 8 6 %降至 5 0 % (P <0 0 1) ,17例原静脉注射毒品者复吸时11例改为烫吸 ,1例改为肌肉注射。结论 :纳曲酮能减轻或消除海洛因正性强化作用 ,间接淡化患者对海洛因的渴求程度 ,降低复吸率 ,无明显毒副作用 ;可使静脉注射海洛因者改变滥用方式 。Objective: To investigate the effect of naltrexone on the prevention of drug relapse. Methods: Retrospective study was conducted. The clinical data of 50 drug addicts who administered naltrexone to prevent relapse after detoxification were analyzed. Results: After six-month administration of naltrexone, the scores of craving for heroin decreased from 1.96±s 0.88 to 0.25±s 0.44; the relapse rate decreased from 28.6% to 5.0%; of 17 former intravenous injecting drug users, when they relapsed, 11 changed to snorting and one changed to in.Conclusion: Naltrexone can alleviate or even eliminate the positive enforcement of heroin so that it can reduce the addicts' craving for heroin and the rate of their relapse. The adverse reaction is slight.

关 键 词：纳曲酮 海洛因依赖 药物治疗 抗复吸 阿片受体拮抗剂 

分 类 号：R971[医药卫生—药品] R595.5[医药卫生—药学]