四种降压药单独长疗程治疗高血压病的疗效对比分析  

A comparative study of the long term effect of 4 different drugs in essential hypertension

作　　者：张美祥[1] 姚淙[1] 王定胜[1] 张德银 姜婉莹 黄达梅[1] 李培[1] 车正兰[1] 张胜学 吴立荣[1] 卢源[1] 

机构地区：[1]贵阳医学院内科教研室,550004

出　　处：《临床心血管病杂志》1992年第3期133-137,共5页Journal of Clinical Cardiology

摘　　要：应用CTP、IDP、ATL、NIT等四种降压药物对325例轻、中度高血压病进行了单药长疗程(1～2年)治疗研究,并设对照组50例与之比较,结果表明:四种药物的降压效果均极显著优于对照组,以IDP的显效率最高。四种药物对血脂、血糖、尿酸、肌酐等均无不良影响,对心脑并发症可能有预防效果。治疗前血压愈高,其降压效果愈佳。体重指数仅在ATL组示低指数者疗效明显优于高指数者,相关分析亦显示密切负相关。副作用均较轻微。通过综合分析,认为四种药物均可作为第一线降压药,并以IDP最优,可为首选,其次为NIT、ATL和CTP。325 cases of mild to moderate essential hypertension were treated alone for 1 -2 years with each of captopril, indapamide, atenolol and nitrendipine. Another 50 cases were treated by placebo as control. Significant therapeutic effect was observed in all 4 treated group. The best result was in IDP treated group. There Were no deteriorative effects on blood lipid, glucose, uric acid and creatinine. There might be preventive effects on cardiac and cerebral complications. The degree of blood pressure reducing was positivaly corralated with pretreating MAP in all 4 groups. All the cases tolerated the drugs very well and only a few mild side effects were experienced. Relative more side effects were seen in the CTP group and the least in the ATL. group. The results suggest that all 4 drugs may be used as the first line of antihypertensive drugs, and IDP is the best one to be selected. CTP may be the drug of first choice for serious hypertension or patients with cardiac and cerebral complications.

关 键 词：卡托普利 吲达伯胺 高血压 

分 类 号：R544.105[医药卫生—心血管疾病]