“90增血剂”对特发性血小板减少性紫裥患者的T细胞亚群的作用  

The Effect of the Chinese Herbsmedicine Preparation “90 Blood--Promotion” on the Subgroups of T--cells in ITP Patients

作　　者：李戈[1] 刘爱菊[1] 严晓梁[1] 郭晋蓉[1] 

机构地区：[1]四川省人民医院,邮政编码610072

出　　处：《临床血液学杂志》1992年第4期148-151,共4页Journal of Clinical Hematology

基　　金：四川省中医药管理局资助

摘　　要：作者根据现代免疫学观点,自1989年起采用自制中药“90增血剂”治疗ITP46例。期间,应用间接免疫荧光技术检测了患者外周血T淋巴细胞亚群,结果表明病例组全T细胞(CD_3)、T辅助/诱导细胞(CD_4)降低,T抑制/细胞毒细胞(CD_8)增高,CD_4/CD_8比值明显降低。治疗后,患者T亚群恢复常态,血小板数上升,骨髓产板型巨核细胞数增加,临床总有效率达91.2%,明显优于激素组(71.4%)。提示中药具有显著的疗效和良好的免疫调节作用。同时,动态观察ITP患者T细胞亚群的变化,对帮助临床判断治疗反应和预后有很大意义。Since 1989, we have treated 46 ITP cases with the selt-made Chineseherbsmedicine preparation '90 blood-promotion' on the basis of modern immunology. Inthe course of the treatment, we have tested the subgroupe of T-lymphocytes in the peripheralblood by using the indirect immunologic flurescent technique. It has been found in the casegroup that the total T-cells (CD_3) and T-helperl/inducer cells(CD_4) were decreased whileT-inhibitor/cellular toxic cells(CD_8) were increased and CD_4/CD_8 value was remarkably re-duced. After the therapy, T-cell group in the patients was restored to normal, and thethrombocyte count and the number of the macronucclic cells that produce thrombocytes inthe marrow were elevated. The total effectiveness reached 91.2%, much more superior tothat of the hormone group (71.4%). It has been shown that the Chinese herbsmedicinePreparation can offer a more satisfictory theraputic and immunologic effecf on the disease.It also has been suggested that the simutaneous dynamic observation in ITP patients is ofgreat importance in the clinical determination of the reaction to the therapy and considerationof the prognosis.

关 键 词：90增血剂 紫癜 T细胞亚群 

分 类 号：R554.605[医药卫生—血液循环系统疾病]