2,5-噻吩双酰腙的合成  

Syntheses and characterizations of 2,5-thiophenediacyhydrazones

作　　者：倪青玲[1] 覃江克[1] 苏桂发[1] 牟红涛[1] 谢建武[1] 黄世稳[1] 黄国生[2] 

机构地区：[1]广西师范大学化学化工系,广西桂林541004 [2]兰州大学化学化工学院,甘肃兰州730000

出　　处：《化学研究与应用》2003年第4期541-543,共3页Chemical Research and Application

基　　金：广西师大青年科学基金资助课题

摘　　要：2,5thionphendicarboxylic acid,which was produced from adipic acid and thionyl chloride,was esterified,hydrazinnolized and then condensated with aroyladehydes in glacial acetic acid to synthesize seven new 2,5thiophenediacylhydrazones in soft conditions with high yields,especially the reaction was finished very quickly(from several seconds to ten minutes)and the workup was simple too.These new compounds were characterized by elementary analysis,IR and 1H NMR.2,5thionphendicarboxylic acid,which was produced from adipic acid and thionyl chloride,was esterified,hydrazinnolized and then condensated with aroyladehydes in glacial acetic acid to synthesize seven new 2,5thiophenediacylhydrazones in soft conditions with high yields,especially the reaction was finished very quickly(from several seconds to ten minutes)and the workup was simple too.These new compounds were characterized by elementary analysis,IR and 1H NMR.

关 键 词：2 5-噻吩双酰腙 合成 缩合 表征 抗肿瘤活性 生物活性 

分 类 号：O626.12[理学—有机化学] R979.1[理学—化学]