失血性休克加内毒素血症大鼠脑内肿瘤坏死因子α的变化  

Change of tumor necrosis factor-α in the brain of rats with hemorrhagic shock and endotoxemia

作　　者：王新春[1] 刘北彦[1] 许平[1] 景慧[1] 刘雪松[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院急诊科,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2003年第4期299-301,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅课题 ( 95 5 10 66)

摘　　要：目的　探讨内毒素对大鼠脑内肿瘤坏死因子α(TNF α)含量的影响。方法　注射内毒素加失血性休克建立实验模型 ,放射免疫法测定大鼠脑内TNF α含量的变化情况。结果　比较实验组与对照组大鼠脑内TNF α含量 ,在内毒素血症早期脑内TNF α变化不明显 (8h ,P≥ 0 .0 5 ) ;随内毒素血症的进展 ,TNF α逐渐升高 (2 4h ,P <0 .0 5 ) ;继而显著增加达峰值 (36h ,P <0 .0 1)。结论　在内毒素血症早期脑内TNF α含量相对稳定 ,脑组织遭受体内过度炎性反应的侵害不明显 ,表明脑组织对体内早期失控的炎性反应敏感性较低。这可能是多系统器官功能障碍综合征神经系统出现功能障碍较晚的原因之一。脑内TNF α含量呈时间依赖性增加 ,TNF α逐步失去其保护功能成为致损伤因子。Objective To study the effect of endotoxin on TNF α in the brain of rats.Methods The rat model was set up by injecting endotoxin and hemorrhagic shock.The level of TNF α was detected with radioimmunoassy.Results The level of TNF α changed inevidently in both test and control groups in early endotoxemia(8h, P ≥0.05);as endotoxemia progressing,TNF α increased gradually(24h, P <0.05),then increased rapidly and reached the apex(36h, P <0.01).Conclusion The level of TNF α in early endotoxemia changes inevidently,which means the insensitive of brain to the out of control inflammation.That may be one of the reasons that neuraxis' dysfunction happens later.The level of TNF α in the brain shows a time dependent elevation,and TNF α will lose its protective function gradually and become a damage factor.

关 键 词：失血性休克 内毒素血症 大鼠 脑内肿瘤 肿瘤坏死因子Α 

分 类 号：R605.971[医药卫生—急诊医学] R363[医药卫生—外科学]