前列腺素E_1对尸体肾移植术后肾功能延迟恢复的影响  

Clinical research of alprostadil (prostaglandin E_1) in cadaveric renal recipients with delayed graft function after transplantation

作　　者：明爱民[1] 林民专[1] 范礼佩[1] 顾新伟[1] 赵明[1] 

机构地区：[1]第一军医大学珠江医院器官移植科,广州510282

出　　处：《临床泌尿外科杂志》2003年第8期458-460,共3页Journal of Clinical Urology

摘　　要：目的 :探讨前列腺素E1(PGE1)应用于尸体肾移植术后肾功能延迟恢复 (DGF)患者对移植肾功能恢复的影响。方法 :回顾性分析因急性排斥 (AR)和急性肾小管坏死 (ANT)导致DGF的 12 7例临床资料 ,其中应用PGE1治疗 5 6例 (PGE1组 ) ,未用PGE1者 71例 (对照组 )。比较两组在出现DGF后的透析治疗时间、肾功能恢复情况、彩超的移植肾血流阻力指数 (RI)及 6个月内AR发生率。结果 :与对照组比较 ,PGE1组透析治疗时间明显缩短 (P <0 .0 5 ) ,移植肾的血肌酐下降速度快 (P <0 .0 5 ) ,RI及 6个月内AR发生率低 (P <0 .0 5 )。结论 :PGE1有利于尸体肾移植术后DGF患者移植肾功能的早期恢复 。Purpose:To assess whether alprostadil (prostaglandin E1, PGE1) has a role in improve renal function among cadaveric renal recipients with delayed graft function(DGF) after transplantation. Methods:To summarize the data, retrospective, of 127 cadaveric renal recipients with DGF who were undergoing acute rejection (AR) or acute tubular necrosis(ATN): 56 of them were given alprostadil (PGE 1 treatment group), the other without alprostadil being given(control group).The time of dialysis treatment 、mean data of creatinine decreasing during renal function recovery(MDC)、the renal blood flow resistance indexes (RI) under Doppler ultrasound and the incidence of AR after DGF were compared between the two group. Results:Comparing with control group: the time of dialysis treatment was significantly shorter(P< 0.05 ); MDC was significantly higher(P< 0.05 ); RI and the incidence of AR showed a significantly lower(P< 0.05 ).Conclusions:The addition of alprostadil to renal recipients can improve early graft function and reduce the incidence of AR.

关 键 词：前列腺素E1 尸体 肾移植 术后 肾功能延迟恢复 影响 治疗 

分 类 号：R699.2[医药卫生—泌尿科学]