0～14岁儿童血肥胖抑素含量及其意义  

Blood Leptin level of 154 Chinese children 0-14 years of age

作　　者：丁宗一[1] 许婉宁[1] 杜丽蓉[1] 

机构地区：[1]北京市儿科研究所,100045

出　　处：《中华儿科杂志》2003年第7期486-492,共7页Chinese Journal of Pediatrics

基　　金：北京市自然科学基金资助 (7972 0 12 )

摘　　要：目的　了解 0～ 14岁儿童血肥胖抑素 (Leptin)水平。方法　对 15 4名 (男 78名 ,女 76名 ) 0～ 14岁健康非肥胖儿童 (38例 )和超重 肥胖儿童 (39例 )的Leptin分布、性别 年龄变化趋势、与人体测量学参数 (腰围、腰臀比、瘦体重、全身体脂含量、体脂百分数、BMI Kaup指数 )和血胰岛素水平的相互关系进行了研究。结果　 (1)健康非肥胖儿童Leptin值为 1 0 1～ 2 9 92 (ng ml) ,均值为 2 99±2 13(ng ml)。 90 %可信限范围 ,男童为 1 36～ 14 2 1(ng ml) ,女童为 1 74～ 2 1 17(ng ml)。血浆与血清Leptin值差异无显著意义 ;(2 )超重 肥胖儿童血Leptin值明显高于非肥胖儿童 (P <0 0 0 1)。 (3)Leptin性别差异有显著意义 (P =0 0 2 3) ,在非肥胖儿童中更明显 (P =0 0 0 4 )。多元回归分析表明 ,加入体脂因素后性别因素不再与Leptin水平相关 (P =0 138,0 2 4 1,0 990 ) ,而BMI、体脂含量和体脂百分数的影响差异有显著意义 (P <0 0 0 1) ;(4)Leptin值与年龄存在相关关系 (P =0 0 0 5 ) ,超重 肥胖组更著 ,女性随年龄增长而升高的趋势更明显 (P =0 0 0 1)。青春期前期Leptin值开始上升 ,女性明显高于男性 (P =0 0 4 5 )。不同年龄组其Leptin值明显不同 (P <0 0 0 1)。 (5 )Leptin值与BMI。Objective To study blood Leptin level of 154 (78 male,76 female) Chinese obese/non-obese children aged 0-14 years during 1999-2001. Methods The gender- and age-specific distribution pattern of Leptin and its relationship with anthropometric parameters (waist circumference, waist/hip ratio, lean body mass, fat mass, body fat percentage, BMI/Kaup index etc.) and blood insulin level were recorded. Results (1) The blood Leptin level in healthy non-obese kids ranged from 1.01-29.92 (ng/ml), the mean values and SD were 2.99±2.13 (ng/ml) [90% confidence interval was 1.36-14.21 (ng/ml) in boys and 1.74-21.17 (ng/ml) in girls]. There was no significant difference in the blood Leptin level between serum and plasma. (2) The blood Leptin level was higher in overweight/obese kids than that in non-obese kids (P<0.001). (3) There was significant difference in the blood Leptin levels between boys and girls groups(P=0.023), especially in non-obese group(P=0.004). The multiple regression analysis showed that there was no correlation between gender and blood Leptin level when body fat factor was added(P=0.138, 0.241,0.990), but there was still a strong correlation between blood leptin level and BMI, FM and BF%(P<0.001). (4) There was a correlation between blood Leptin level and age(P=0.005), especially in overweight/obese group and in girls (P=0.001). The blood Leptin level rose from early puberty, especially in girl group (P=0.045). There was significant difference in blood Leptin level in different age groups(P<0.001) (5) There were strong positive correlation between blood Leptin level and BMI, BM and FM%, a weak correlation with LBM, and no correlation with W/H ratio in boys and a positive relationship in girls. The Quatatic equation was better than the linear equation in description of the correlation mentioned above. (6) There was a correlation between blood Leptin from 0 to 7 yr and birth weight (P=0.001), after 7 yr of age this correlation disappeared (P=0.456). (7) A positive correlation was seen between blood Leptin l

关 键 词：儿童 血肥胖抑素 含量 肥胖 胰岛素 人体质量指素 

分 类 号：R174[医药卫生—妇幼卫生保健]