前列腺素E_1脂微球载体剂治疗心绞痛的临床疗效  

Clinical therapeutic efficiency of lipo-prostaglandin E_1 injection on angina pectoris

作　　者：闫农[1] 张树新[1] 刘淑媛[1] 杨冬梅[1] 唐文睿[1] 

机构地区：[1]中国人民解放军第309医院急诊科,北京100091

出　　处：《中国临床药学杂志》2003年第4期201-203,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的:观察前列腺素E_1脂微球载体剂(Lipo PGE_1)治疗冠心病心绞痛的临床疗效。方法:将120例冠心病心绞痛患者,在常规治疗基础上分为:治疗组(60例)应用lipo PGE_1 10μg+NS 100mL,iv gtt,qd×10 d;对照组(60例)用复方丹参注射液20mL+5％GS250mL,iv gtt,qd×14d。观察治疗前后患者心绞痛缓解情况、ECG ST-T变化及血液流变学变化。结果:治疗组的心绞痛缓解率、ECG ST-T改变和血小板聚集率与对照组比较差异显著(P<0.01～0.05)。治疗组血小板计数、凝血酶原时间及血浆黏度变化与对照组相似(P>0.05)。结论:Lipo PGE_1治疗冠心病心绞痛疗效显著,使用方便,无明显不良反应。AIM: To explore the clinical efficacy of lipo-prostaglandin E1(Lipo PGE1) injection on angina pectoris of coronary heart disease. METHODS: One hundred and twenty five cases of angina pectoris were divided randomly into treatment group (n = 60), which treated with Lipo PGE1 10 μg added to NS 100 mL, iv gtt, qd for 10 d and control group ( n = 60), which treated with salvia miltiorrhiza injection 20 mL added to 5% glucose injection 250 mL, iv gtt, qd for 14 d. RESULTS: The total alleviating rate of angina pectoris and changing ST-T in ECG and reducing platelet aggregation rate in treatment group were higher obviously than those in control group (P<0.01-0.05). There was no significant difference in platelet count, plasma prothrombin time and plasma viscosity between treatment group and control group ( P > 0.05) . CONCLUSION: There have many merits of Lipo PGE1 injection treating angina pectoris of coronary heart disease including better therapeutic efficacy, convenient use, no poisonous and adverse drug reaction.

关 键 词：前列腺素E1脂微球载体剂 治疗 心绞痛 临床疗效 复方丹参注射液 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病] R972.3[医药卫生—内科学]