手性相转移催化剂的合成及其不对称诱导效应Ⅰ——(1S,2R)-(一)-(1-对硝基苯基-1,3-二羟基-2-丙基)三甲基碘化铵  

Synthesis and asymmetric Induction of chiral phase transfer catalysts 1--(1S,2R)-(-)-(1-paranitrophenyl-1,3-dihydrox-yl-2-propyl) trimethylammonium iodide

作　　者：华玉夏[1] 焦晓云[1] 刘文陆[1] 矫桂丽[1] 邹志琛[1] 

机构地区：[1]山东师范大学化学系,山东济南250014

出　　处：《化学试剂》2003年第4期201-202,228,共3页Chemical Reagents

摘　　要：以氯霉素为原料,经水解、叔胺化、季铵化合成了光学纯(1S,2R)-(-)-(1-对硝基苯基-1,3-二羟基-2-丙基)三甲基 碘化铵,作为相转移催化剂,它对苯乙腈的α-甲基化、苯甲醛与氯仿的亲核加成均显示良好的催化作用和一定的不对称 诱导效应。(1S, 2R)-(-)-(1-Para-nitrophenyl-1,3-dihydroxyl-2-propyl) trimethylammonium iodide was synthesized through hydrolysis, tert-aminolation and quaterization by beginning with chioramphenicol, and as a phase transfer catalyst, it shows good catalytic and certain asymmetric induction effect in a-methylation of phenylacetonitrile, and in addition of benzaldehyde with chloroform.

关 键 词：手性相转移催化剂 合成 不对称诱导效应 (1S 2R)-(—)-(1-对硝基苯基-1 3-二羟基-2-丙基)三甲基碘化铵 手性化合物 

分 类 号：TQ426[化学工程] O643.36[理学—物理化学]