^(89)SrCl_2溶液中载体含量对其在动物体内分布的影响  

The Influence of ^(89)SrCl_2 Solution With Different Amount Carrier on Biodistribution in Mice

作　　者：陈大明[1] 杨志[2] R.A.Kuznetsov 张岩[2] 郭红原[1] 孙寿涛[1] 杨红伟[1] 祁本忠[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413 [2]北京大学临床肿瘤学院北京肿瘤医院核医学科,北京100036 [3]State Scientific Center,Research Institute of Atomic Reactors

出　　处：《同位素》2003年第2期78-82,共5页Journal of Isotopes

摘　　要：利用89Y(n,p)89Sr反应在快中子反应堆中制得高比活度89Sr并将其溶于0.01mol/LHCl中,之后加入不同量的SrCl2配制成不同载体含量的溶液;将所得溶液注入正常小鼠体内进行体内分布及急性毒性研究。结果表明:制备的89SrCl2溶液是无菌无热原的澄明溶液,89SrCl2的核纯度>99%,90Sr的含量<1×10-4%,其它伽玛杂质<1×10-2%,89Sr的比活度>185TBq/g,满足医用要求;89SrCl2溶液特异性浓聚于骨,在24h内达到最高,在其它组织中浓聚较少;89SrCl2溶液的载体含量对其在小鼠体内的分布有明显影响,高比活度组(0.5mg/L)在骨中最高浓聚为80.2%(ID%),且7天内骨中的浓聚都显著高于其他组;载体含量对正常小白鼠有较大的毒性,其半致死剂量约为3mg,安全剂量<1mg。The biodistribution of the 89SrCl2 solution with different amount carrier are studied. The results show that 89Sr is concentrated in bone mostly, up to maximum within 24 h, and the concentration of 89Sr in bone is affected obviously by the amount of SrCl2 in the 89SrCl2 solution. The bone concentrations of the group of high specificactivity (maximum is 80.2 ID%/g) are always higher remarkably than those of other groups (SrCl2 concentration is 0.1?0.5?2.5 and 100 g/L) in 7 days. The SrCl2 has toxicity, the half dosage caused death is about 3 mg for normal mice and the safety dosage is <1 mg.

关 键 词：^89SrCl2溶液 载体 动物 影响 急性毒性 比活度 剂量 骨转移 

分 类 号：R817.5[医药卫生—影像医学与核医学]