^(153)Sm-葡庚糖酸钠的制备  

The Preparation of ^(153)Sm-glucoheptonate

作　　者：蒲满飞[1] 罗顺忠[1] 刘业兵[1] 刘国平[1] 王文进[1] 陈琪萍[1] 刘中林[1] 傅依备[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,四川绵阳621900

出　　处：《同位素》2003年第2期83-87,共5页Journal of Isotopes

基　　金：中国工程物理研究院基金资助项目(970564)

摘　　要：研究了制备条件对153Sm标记GH的影响及标记物的体外稳定性,建立了有效的153Sm标记葡萄糖酸钠(GH)方法。结果表明:用通氮敞开体系、沸水浴加热的标记方法,反应时间不低于30min,GH浓度不低于2.4×10-2mol/L时,可获得标记率大于98%的153Sm-GH;用高比活度153Sm(～4.5TBq/g(Sm))标记,其比活度可达14GBq/g(GH)。该标记物在室温下具有较好的稳定性,放置40h内,其放化纯度>96%。Influences of labeling conditions on the formation of glucoheptonate (GH) labeled with 153Sm and in vitro stability of 153SmGH are investigated. The effective labeling method of GH labeled with 153Sm is established. The results show that the labeling yield of 153SmGH is more than 98% using an open nitrogenpouring labeling system heated in boiling water bath with reactive time not less than 30 min, concentration of GH more than 2.4×10-2 mol/L. The specific activity of 153SmGH is up to 14 GBq/g(GH) using 153SmCl3 with the high specific activity of 153Sm (～4.5 TBq/g(Sm)). 153SmGH can remain well with its radioactive chemical purity more than 96% within 40 hours at room temperature.

关 键 词：^153Sm-葡庚糖酸钠 制备 稀土核素 标记率 肿瘤 治疗 

分 类 号：R817.5[医药卫生—影像医学与核医学]