血糖浓度对荷瘤小鼠^(18)F-FDG体内分布的影响  

The Influence of Blood Glucose Level on Distribution of ^(18)F-FDG in Mice With Tumor

作　　者：付占立[1] 林景辉[1] 王荣福[1] 朱绍莉[1] 张春丽[1] 潘中允[1] 

机构地区：[1]北京大学第一医院核医学科,北京100034

出　　处：《同位素》2003年第2期88-91,共4页Journal of Isotopes

摘　　要：为探讨血糖浓度对荷瘤小鼠18F-FDG体内分布的影响,取35只皮下接种艾氏腹水癌(EAC)一周后的小鼠禁食20h,随机分为对照组(n=11)与糖负荷组(n=12),分别给予蒸馏水和50%葡萄糖0.5mL灌胃,另有两组分别给予10%葡萄糖(5只)和30%葡萄糖(7只)0.5mL灌胃,1h后测血糖并尾静脉注射18F-FDG,再1h后放血处死,计算各组织SUV及肿瘤SUVc。糖负荷组荷瘤小鼠血糖浓度(11.98±3.01mmol/L)较对照组(3.95±1.11mmol/L)显著升高(P<0.01);糖负荷组小鼠的肿瘤、脑、脾、血SUV及肿瘤与肌肉摄取比(1.34,0.86,0.48,0.09,1.38)显著低于对照组(3.02,2.62,0.80,0.16,5.38)(P<0.01),心、肌肉SUV及肿瘤与脑、心与血摄取比(8.31,1.05,1.58,103.00)显著高于对照组(1.57,0.64,1.20,9.73)(P<0.01);肺、肝、肾SUV及肿瘤SUVc在两组间无显著差异(P>0.05)。肿瘤、脑、脾、血SUV及肿瘤与肌肉摄取比与血糖浓度呈显著性负相关,r分别为:-0.76,-0.92,-0.78,-0.48,-0.63(P<0.01);心、肌肉SUV及肿瘤与脑、心与血摄取比、肿瘤SUVc与血糖浓度呈显著性正相关,r分别为:0.85,0.43,0.51,0.85,0.45(P<0.01)。结果表明,血糖浓度变化显著影响荷瘤小鼠肿瘤及正常组织对18F-FDG的摄取。To explore the influence of blood glucose level on 18FFDG uptake in tumor and normal tissues of mice, thirtyfive mice carrying Ehrlich ascitic cancer (EAC) are fasted 20 h and divided into four groups. The glucose loading group (n=12) and the control group (n=11) is given a solution of 50% glucose and distilled water orally just one hour before the 18FFDG injection. Another two groups (n=5, n=7) is given a solution of 10%, 30% glucose respectively. Before 18FFDG intravenous injection, blood glucose levels are measured. The mice are killed one hour after the 18FFDG injection. The tumor and normal tissues are excised, weighed, and counted by a γ well counter. The quantity of 18FFDG uptake is expressed as standardized uptake value (SUV). Blood glucose levels of the mice with EAC in the glucoseloading group are significantly elevated than the control group (11.98±3.01 mmol/L vs. 3.95±1.11 mmol/L, P<0.01). The SUVs of tumor, brain, spleen, blood and the 18FFDG uptake ratios of tumor and muscle in the glucoseloading group (1.34, 0.86, 0.48, 0.09, 1.38 respectively) are significantly lower than those in the control group (3.02, 2.62, 0.80, 0.16, 5.38 respectively) (P<0.01). The SUVs of heart and muscle, the 18FFDG uptake ratios of tumor and brain, heart and blood in the glucoseloading group (8.31, 1.05, 1.58, 103.00 respectively) are significantly higher than those in the control group (1.57, 0.64, 1.20, 9.73 respectively) (P<0.01). There are no difference betweene the two groups in the SUV of lung, liver and kidney, and in the tumor SUVc. The correlation of tumor, brain, spleen and blood SUVs and the uptake ratios of tumor and muscle with blood glucose levels are negative, and the correlation coefficients are -0.76, -0.92, -0.78, -0.48 and -0.63, respectively (P<0.01). The correlation of heart, muscle SUVs, the uptake of

关 键 词：血糖浓度 荷瘤小鼠 ^18F—FDG 分布 影响 艾氏腹水癌 EAC 葡萄糖 诊断 显像剂 

分 类 号：R817.4[医药卫生—影像医学与核医学]