新型β_2激动剂SPFF对豚鼠气道的扩张作用研究  

Bronchodilation effect of novel β_2 agonist SPFF in guinea pigs

作　　者：甘乐凌[1] 王澈[1] 王敏伟[1] 程卯生[2] 潘丽[2] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016 [2]沈阳药科大学制药工程学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2003年第5期367-369,共3页Journal of Shenyang Pharmaceutical University

基　　金：国家重点科技攻关项目 (96-90 1 -0 5 -1 3 0 )

摘　　要：目的考察SPFF对组胺和乙酰胆碱所致气管收缩的抑制作用。方法离体豚鼠气管条和豚鼠引喘试验。结果SPFF可完全抑制组胺所引起的气管收缩作用 ,但不能完全抑制乙酰胆碱所引起的气管收缩。SPFF灌胃给药时对由于组胺和乙酰胆碱混合喷雾所引起的豚鼠喘息具有显著的保护作用 ,其作用强于同剂量的沙丁胺醇。Objective To investigate the inhibitory effect of SPFF on histamine and acetylcholine-induced trache constriction in guinea pigs.Methods Isolated guinea pigs′ trachea strips in vitro and bronchospasm induced by histamine and acetylcholine aerosol in vivo in guinea pigs were studied.Results The histamine-induced trachea constriction in guinea pigs was completely inhibited by SPFF,meanwhile,the constriction induced by acetylcholine was only partly cancelled by SPFF.When given i.g,SPFF significantly prolonged the latency time to histamine and the acetylcholine induced collapse.Conclusion SPFF is a potent bronchodilator in guinea pigs.

关 键 词：Β2激动剂 SPFF 气道扩张作用 组胺 乙酰胆碱 

分 类 号：R96[医药卫生—药理学]