冰硼口腔糊剂的研究  

Study of Bingpeng oral paste

作　　者：董世波 张辉[2] 盖平[2] 

机构地区：[1]山东省医药工业研究所,山东济南250100 [2]山东省立医院药剂科,山东济南250022

出　　处：《中成药》2003年第9期703-704,共2页Chinese Traditional Patent Medicine

摘　　要：目的 :借鉴国外专利方法研制冰硼散新剂型。方法 :将药物细粉、粘附和粘度增强剂、非离子表面活性剂和凡士林分散于液体石蜡中制成糊剂 ,并以粘着力、吸水值和赋形性为指标优选高分子材料的种类、比例和用量。结果 :最佳处方为冰硼散 5 .0 g ,羟丙甲纤维素 2 1 .0g ,卡波姆 1 4 .0 g ,甘油单硬脂酸酯 3 .0g ,凡士林 5 .0 g ,液体石蜡加至 1 0 0 .0 g。冰硼口腔糊剂对家免试验性口腔溃疡面愈合时间显著快于冰硼散。结论 :冰硼口腔糊剂使用方便 。Objective:To study new dosage form of Bingpeng powder referring to oversea patent. Methods: To disperse Bingpeng powder, adhesive and viscosity builders (such as gelatin, carboxymethylcellulose, hypromellose or carbomer), nonionic emulsifier (gluceryl monostearate) and white vaseline into liquid paraffin, stir to attain paste. The formulation was screened by adhesive strength, shape keeping characteristic and water asorbing value. Results: The better formulation: Bingpeng powder 5.0g, hypromellose 21.0g, carbomer 14g, gluceryl monostearate 3.0g, white vaseline 7.0g, liquid paraffin to 100.0g; the paste getting rabbits' artificial ulcers healed more quickly than powder does. Conclusion: The paste is applied more expediently and more effective for oral ulcer.

关 键 词：冰硼散 糊剂 口腔溃疡 

分 类 号：R944.9[医药卫生—药剂学]