双辛颗粒质量标准的研究  

Study on quality standard for Shuangxin Granules

作　　者：顾莹[1] 郭五保[1] 王花红[2] 张晔[1] 

机构地区：[1]陕西省中医药研究院实验中心,陕西西安710003 [2]陕西师范大学生命科学学院,陕西西安710062

出　　处：《中成药》2003年第9期711-715,共5页Chinese Traditional Patent Medicine

摘　　要：目的 :建立双辛颗粒 (苍耳子、辛夷、白芷、细辛 ,金银花 ,忍冬藤、蒲公英、甘草 ,桔梗、菊花、黄芩、赤芍、薏苡仁 ,生地 )的质量标准。方法 :采用TLC法为处方中的黄芩、赤芍、白芷、蒲公英、甘草制定了定性鉴别方法 ;用高效液相色谱法制定了制剂中黄芩苷含量的测定方法。结果 :在TLC图谱中可检出黄芩、赤芍、白芷、蒲公英、甘草的特征斑点 ;黄芩苷在 0 .0 590 4～ 0 .3542 4 μg间线性关系良好 ,r =0 .9999。 结论 :所建立的方法准确可靠 ,可用于该制剂的质量控制。Objective: To establish the quality standard for Shuangxin Granules (Fructus Xanthii, Flos Magnoliae, Radix Angelicae Dahuricae, Herba Asari, Flos Lonicerae, Caulis Lonicerae, Herba Taraxaci, Radix Glycyrrhizae, Radix Platycodonis, Flos Chrysanthemi, Radix Scutellariae, Radix Paeoniae Rubra, Semen Coicis and Radix Rehmannia). Methods: Radix Scutellariae、Radix Paeoniae Rubra、Radix Angelicae Dahuricae、Herba Taraxaci、Radix Glycyrrhizae in Shuangxin Granules were identified by TLC,and the content of baicalin was determined by HPLC. Results: Radix Scutellariae、Radix Paeoniae Rubra、Radix Angelicae Dahuricae、Herba Taraxaci、Radix Glycyrrhizae could be identified by TLC. Baicalin showed a good linear relationship at a range of 0.05904～0.35424μg, r =0.9999. Conclusion: The method is accurate and can be used for the quality control of Shuangxin Granules.

关 键 词：双辛颗粒 黄芩 赤芍 白芷 蒲公英 甘草 黄芩苷 质量标准 

分 类 号：R927.2[医药卫生—药学]