隐孔菌对大鼠多形核粒细胞释放白三烯的影响  

Effect of Cryptoporus volvatus (Peck) Schear on Leukotriene Production from Polymorphonuclear Leukocytes in Rats

作　　者：金赛红[1] 谢强敏[1] 林晓霞[1] 邓杨梅[1] 陈季强[1] 

机构地区：[1]浙江大学医学院国家药品监督管理局浙江呼吸药物研究实验室

出　　处：《中国中药杂志》2003年第7期650-653,共4页China Journal of Chinese Materia Medica

基　　金：国家重点科技(攻关)项目(96-901-05-269)

摘　　要：目的:探讨隐孔菌发酵物(CVFS)对大鼠多形核粒细胞释放白三烯的影响。方法:采用生物检定法和HPLC法测定大鼠多形核粒细胞(PMNs)中慢反应物质(SRS)和白三烯B_4(LTB_4)的含量。结果:CVFS 0.9,2.7 g·kg^(-1)ig能明显抑制大鼠PMNs释放LTB_4和SRS。结论:结果证明CVSF可抑制PMNs释放SRS和LTB_4。Objective: To study action of Cryptoporus volvatus ferment substance ( CVFS ) on leukotriene production of poly-morphonuclear leukocytes in rats. Methods: The level of slow reaction substance (SRS) and leukotriene B4 ( LTB4) in polymor-phonuclear leukocytes ( PMNs ) in rats in vitro were determined with bioassay and HPLC. Results: CVFS0.9, 2.7 g·kg-1 by ig significantly inhibited SRS and LTB4 production in PMNs in rats in vivo. Conclusion: The inhibition effect of CVFS on SRS and LTB4 release may be related to its mechanism of anti-inflammation and anti-asthma.

关 键 词：隐孔菌 多形核粒细胞 慢反应物质 白三烯B4 抗炎机制 动物实验 

分 类 号：R285.5[医药卫生—中药学]