高血压患者脉压与大动脉扩张性、内皮功能关系的研究  

Pulse Pressure, Large Artery Distensibility And Endothelial Function In Patients With Hypertension

作　　者：张俊[1] 罗开良[1] 刘增长[1] 殷耀辉[1] 佘强[1] 淡学川[1] 邓昌明[1] 胡容[1] 兰先彬[1] 

机构地区：[1]重庆医科大学附属第二医院心内科,重庆400010

出　　处：《高血压杂志》2003年第4期311-314,共4页Chinese Journal of Hypertension

摘　　要：目的　研究高血压 (EH)患者脉压 (PP)与大动脉扩张性、内皮功能的关系。方法　选择 1 0 9例EH患者 ,其中男性56例 ,女性 53例 ,平均年龄 60 8± 6 2岁。将所有病例按PP值分成四组 ,应用B超声对颈动脉、肱动脉进行扫查 ,在静息、反应性充血时和舌下含服硝酸甘油后对肱动脉内径进行检测。结果　颈总动脉舒张期直径 (DD)随PP增大而增加 ,收缩期与舒张期直径之差 (DS D)及DS D/DD却随PP增大而减小 ,PP与IMT呈正相关关系 ,其相关性强于收缩压 (SBP)、舒张压 (DBP)、平均压 (MAP)。加压充血后 ,肱动脉管径平均扩增 (Flow MD) 3 %～ 1 3 % ,随PP增大 ,Flow MD逐渐减小 ,各组差异有显著性 (P <0 0 5)。结论　PP增大与高血压患者大动脉扩张性降低、管壁增厚 。Objective To explore the relationship between PP and large artery distensibility and endothelial function in patientes with hypertension Methods One hundred and nine patients with hypertension were recruited, 56 male, 53 female with mean age of 60 8±6 2 years old All patients were categorized into 4 groups by PP: Group 1, PP<45 mmHg( n =20);group 2,45～65 mmHg(\%n\%=34);group 3,65～85 mmHg(\%n\%=34) and group 4, PP>85 mmHg(\%n\%=2) All patients were underwent B mode ultrasonic investigation to scan carotid artery The diameter of brachial artery and blood flow during reactive hyperemia and after sublingual glyceryl trinitrite were measured Result In the patients of 2 higher quartiles of group 1 and group 2, the diastolic diameter(DD) of carotid artery was greater than that of patients in 2 lower quartiles, which was in accompany with a smaller differences between diastolic and systolic diameter (DS D) and DS D/DD Among the various parameter of BP, such as SBP, DBP, MAP and PP, the correlation of PP with IMT was the strongest In the patients with greater PP, the less flow mediated dilation(flow MD) was found Conclusion Greater PP was closely related to decreases in distensability in large artery and a reduction in endothelial function in patients with hypertension

关 键 词：高血压 脉压 大动脉扩张性 内皮功能 

分 类 号：R544.1[医药卫生—心血管疾病] R543[医药卫生—内科学]