降压治疗对血清C-反应蛋白和动脉顺应性影响的研究  

The Effect of Antihypertensive Therapy on CRP and Vascular Compliance

作　　者：李新立[1] 蒋素华[1] 倪春辉[2] 张海峰[1] 王震震[1] 黄峻[1] 童明庆[1] 马菜云[1] 

机构地区：[1]南京医科大学第一附属医院,210029 [2]南京医科大学公共卫生学院职环系,210029

出　　处：《心脑血管病防治》2003年第4期16-18,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：江苏省自然科学基金项目 (BK2 0 0 2 0 2 9)

摘　　要：目的　探讨降压治疗对血清C -反应蛋白 (CRP)和动脉顺应性的影响及其临床意义。方法　分别选取正常对照组 6 4例、高血压控制组 36例和高血压未控制组 4 2例 ,使用美国产HDI- 2 0 2 0动脉测试仪同步记录血压和动脉顺应性 (大动脉弹性C1,小动脉弹性C2 ) ,用日本产AU2 70 0全自动生化分析仪检测血脂全项、血糖。用德国产BNprospec免疫比浊仪检测超敏CRP(hsCRP)。用放免法检测血清胰岛素 (Insulin ,INS)水平。结果　高血压未控制组CRP水平明显增高 ,与高血压控制组和正常对照组比较有显著性差异 (P <0 0 1) ,后二组间无统计学意义 (P >0 0 5 )。三组间收缩压(SBP)、舒张压 (DBP)和脉压 (PP)比较均有差异 (P <0 0 1) ,高血压未控制组C1和C2均低于对照组和高血压控制组 (P <0 0 1) ,后二组间无差异 (P >0 0 5 )。三组间相关分析 :高血压未控制组的C1和C2均与胆固醇 (TC)、低密度脂蛋白 (LDL)和CRP分别呈负相关 (r =- 0 4 4 0 ,P <0 0 1;r =- 0 4 4 9,P <0 0 1;r =- 0 35 8,P <0 0 5 ;r =- 0 36 3,P <0 0 5 ;r =-0 4 73,P <0 0 1;r=- 0 2 99,P <0 0 5 )。对照组和高血压控制组的各指标均无相关性。结论　CRP可作为反映降压疗效的指标之一 ,动脉顺应性与TC。Objective To investigate the effect of antihypertensive therapy on C-reactive protein (CRP) and vascular compliance.Methods 142 subjects were divided into three groups:64 normotensive individuals belonged to the control group;36 subjects had controlled hypertension belonged to the EH-controlled hypertension group,and 42 hypertension patients belonged to the EH-uncontrolled group.Blood pressure and artery compliance (C1-large artery,C2-small artery) were detected by HDI DO-2020 instrument.Blood lipid profile and fasting blood glucose(FBG) were measured by AU2700 Automatic Biochemistry Analyzer and CRP was measured by BNprosec Immune Nephelometry.Serum insulin was measeured by RIA.Results The concentration of CRP of EH-uncontrolled group was markedly increased,there was a significant difference between EH-uncontrolled and control and EH-controlled groups (P<0 01),but there was no statistical difference between control and EH-controlled groups (P>0 05).SBP,DBP and PP among three groups were remarkably different (P<0 01).Both C1 and C2 in EH-uncontrolled group were significantly lower than those in control and EH-controlled groups (P<0 01).Correlation analysis:both C1 and C2 in EH-uncontrolled group were negative correlation to TC,LDL and CRP(r=-0 440,P<0 01;r=-0 449,P<0 01;r=-0 358,P<0 05;r=-0 363,P<0 05;r=-0 473,P<0 01;r=-0 299,P<0 05,respectively).There were no correlation of all indices between the control and EH-controlled groups.Conclusions CRP is regarded as one of indices in evaluating the effect of antihypertensive therapy.The correlation between vascular compliance (C1,C2) and TC,LDL and CRP was better than the other blood indices.

关 键 词：高血压 降压治疗 血清 C-反应蛋白 动脉顺应性 影响 临床意义 

分 类 号：R544.1[医药卫生—心血管疾病]