SARS相关抗肺自身抗体产生机制的初步研究  

Production of SARS-related anti-lung autoantibodies

作　　者：陈昊[1] 李伯安[1] 赵军[1] 何卫平[1] 郑宇[1] 李靖[1] 高蓉[1] 程云[1] 

机构地区：[1]解放军第302医院传染病研究所免疫研究室,北京100039

出　　处：《第二军医大学学报》2003年第8期823-824,共2页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金 ( 3 0 3 40 0 10 ) ;北京市自然科学基金 ( 70 3 0 45 0 )

摘　　要：目的 :检测严重急性呼吸综合征 (SARS)患者血清中抗 SARS病毒抗体与肺组织的反应性。 方法 :采用酶联免疫吸附法检测 SARS患者恢复期血清中抗 SARS病毒抗体 ,并采用肺组织与抗体共同孵育的方法 ,吸附抗 SARS病毒抗体中同肺组织反应的 SARS相关抗体。结果 :与肺组织共同孵育后 ,抗 SARS病毒抗体被部分中和 ,中和率为 13.6 %～ 32 .2 %。结论 :部分抗 SARS病毒抗体可以与肺组织反应 ,SARS病毒抗原同肺组织抗原有部分同源性。机体对 SARS病毒抗原和肺组织的交叉免疫性可能是Objective:To analyze the cross reactivity of SARS related autoantibodies and lung tissues. Methods: The anti SARS virus antibodies were detected by ELISA. Antibodies cross reative with SARS virus and lung tissues were absorbed by lung tissue. Results: After absorption by lung tissues,the anti SARS virus antibodies in the sera of SARS patients were partly absorbed; the absorption rate of IgG ranged from 13.6% to 32.2%. Conclusion: Part of anti SARS virus antibodies can react with lung tissue. There are possible common epitopes between SARS virus and lung tissue. Cross reactivity can partly explain the production of SARS related anti lung autoantibodies in the sera of SARS patients.

关 键 词：严重急性呼吸综合征 SARS 自身抗体 肺组织反应性 酶联免疫吸附法 

分 类 号：R563.1[医药卫生—呼吸系统]