左旋卡尼汀对充血性心衰患者血清超氧化物歧化酶和丙二醛水平的影响  

Effects of L-carnitine on superoxide dismutase and malondialdehyde levels in patients with congestive heart failure

作　　者：周翠玲 殷仁富[1] 信栓力[1] 王咏梅[1] 左明良[1] 

机构地区：[1]第二军医大学长征医院心血管内科,上海200003

出　　处：《第二军医大学学报》2003年第8期916-917,共2页Academic Journal of Second Military Medical University

基　　金：全军医学科学技术研究"十五"规划面上课题基金( 0 1M0 0 2 ) .

摘　　要：选择充血性心衰 (CHF)患者 5 0例随机分为两组 ,对照组 (2 5例 )予常规药物治疗 ,左旋卡尼汀 (L- CN)组 (2 5例 )予常规药物 +L- CN治疗。采用化学定量法检测两组血清丙二醛 (MDA)和超氧化物歧化酶 (SOD)含量。结果发现 ,治疗前 L- CN组和对照组比较 ,血清 SOD和 MDA水平没有显著性差异 ;治疗后 L- CN组和对照组比较 ,SOD水平显著上升 ,MDA水平显著下降 (P<0 .0 1)。提示 L- CN可能对This paper is to investigate the effects of L carnitine( L CN) on levels of superoxide dismutase(SOD) and malondialdehyde(MDA) in patients with congestive heart failure(CHF). Fifty patients with CHF were randomly divided into control group and L CN group( n =25). The control group received routine medication: digitalis,diuretics,vasodilator,ACEI and β receptor blocker while the L CN group was given intravenous L CN 3.0 g for 10 d. The blood samples for assay of serum SOD and MDA levels were taken before and after treatment. The concentration of SOD in L CN group was significantly increased [(110.15±4.19) vs (94.54±4.0) μU/ml, P <0.01] and the levels of MDA significantly decreased compared with that of control group [(4.81±1.83) vs (7.71±1.18) μmol/ml, P <0.01]. L CN may protect myocardium in CHF patients.

关 键 词：充血性心衰 左旋卡尼汀 治疗 血清 超氧化物歧化酶 丙二醛 

分 类 号：R541.6[医药卫生—心血管疾病] R972.1[医药卫生—内科学]